TY  - JOUR
AU  - Jia, Min
AU  - Zhang, Yan
AU  - Jansen, Lina
AU  - Walter, Viola
AU  - Edelmann, Dominic
AU  - Gündert, Melanie
AU  - Tagscherer, Katrin E
AU  - Roth, Wilfried
AU  - Bewerunge-Hudler, Melanie
AU  - Herpel, Esther
AU  - Kloor, Matthias
AU  - Ulrich, Alexis
AU  - Burwinkel, Barbara
AU  - Bläker, Hendrik
AU  - Chang-Claude, Jenny
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
TI  - A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival.
JO  - Clinical epigenetics
VL  - 11
IS  - 1
SN  - 1868-7083
CY  - [S.l.]
PB  - BioMed Central
M1  - DKFZ-2019-01903
SP  - 109
PY  - 2019
AB  - Results of previous studies on the association of the CpG island methylator phenotype (CIMP) with colorectal cancer (CRC) prognosis were inconsistent and mostly based on different CIMP definitions. The current study aimed to comprehensively investigate the associations between DNA methylation on genes previously used to define CIMP status with CRC survival.Patients with CRC followed up for a median of 5.2 years were divided into a study cohort (n = 568) and a validation cohort (n = 308). DNA methylation was measured in tumor tissue using the Illumina Infinium HumanMethylation450 BeadChip and restricted to 43 genes used to define CIMP status in previous studies. Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HR) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:31340858
C2  - pmc:PMC6657180
DO  - DOI:10.1186/s13148-019-0703-4
UR  - https://inrepo02.dkfz.de/record/144451
ER  -