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@ARTICLE{Ehrlich:144478,
      author       = {F. Ehrlich and M. Laggner and L. Langbein$^*$ and P. Burger
                      and A. Pollreisz and E. Tschachler and L. Eckhart},
      title        = {{C}omparative genomics suggests loss of keratin {K}24 in
                      three evolutionary lineages of mammals.},
      journal      = {Scientific reports},
      volume       = {9},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2019-01929},
      pages        = {10924},
      year         = {2019},
      abstract     = {Keratins are the main cytoskeletal proteins of epithelial
                      cells and changes in the expression of keratins have
                      contributed to the evolutionary adaptation of epithelia to
                      different environments. Keratin K24 was proposed to be a
                      differentiation marker of epidermal keratinocytes but the
                      significance of K24 expression in the epidermis versus other
                      tissues has remained elusive. Here, we show by RT-PCR,
                      western blot, and immunofluorescence analyses that K24 is
                      highly expressed in the epithelium of the cornea whereas its
                      expression levels are significantly lower in other
                      stratified epithelia including in the epidermis. To
                      investigate the evolutionary history of K24, we screened the
                      genome sequences of vertebrates for orthologs of the human
                      KRT24 gene. The results of this comparative genomics study
                      suggested that KRT24 originated in a common ancestor of
                      amniotes and that it was lost independently in three clades
                      of mammals, i.e. camels, cetaceans, and a subclade of
                      pinnipeds comprising eared seals and the walrus. Together,
                      the results of this study identify K24 as component of the
                      cytoskeleton in the human corneal epithelium and reveal
                      previously unknown differences of keratin gene content among
                      mammalian species.},
      cin          = {A110},
      ddc          = {600},
      cid          = {I:(DE-He78)A110-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31358806},
      pmc          = {pmc:PMC6662840},
      doi          = {10.1038/s41598-019-47422-y},
      url          = {https://inrepo02.dkfz.de/record/144478},
}