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000144480 041__ $$aeng
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000144480 1001_ $$aIsenmann, Eduard$$b0
000144480 245__ $$aEcdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans.
000144480 260__ $$aHeidelberg$$bSpringer$$c2019
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000144480 520__ $$aRecent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in a recent study performed in rats. However, scientific studies in humans are very rarely accessible. Thus, our project aimed at investigating the effects of ecdysterone-containing products on human sport exercise. A 10-week intervention study of strength training of young men (n = 46) was carried out. Different doses of ecdysterone-containing supplements have been administered during the study to evaluate the performance-enhancing effect. Analysis of blood and urine samples for ecdysterone and potential biomarkers of performance enhancement has been conducted. To ensure the specificity of the effects measured, a comprehensive screening for prohibited performance-enhancing substances was also carried out. Furthermore, the administered supplement has been tested for the absence of anabolic steroid contaminations prior to administration. Significantly higher increases in muscle mass were observed in those participants that were dosed with ecdysterone. The same hypertrophic effects were also detected in vitro in C2C12 myotubes. Even more relevant with respect to sports performance, significantly more pronounced increases in one-repetition bench press performance were observed. No increase in biomarkers for liver or kidney toxicity was noticed. These data underline the effectivity of an ecdysterone supplementation with respect to sports performance. Our results strongly suggest the inclusion of ecdysterone in the list of prohibited substances and methods in sports in class S1.2 'other anabolic agents'.
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000144480 7001_ $$aAmbrosio, Gabriella$$b1
000144480 7001_ $$aJoseph, Jan Felix$$b2
000144480 7001_ $$aMazzarino, Monica$$b3
000144480 7001_ $$ade la Torre, Xavier$$b4
000144480 7001_ $$0P:(DE-He78)d05b24af674d8ef2c455634434b67770$$aZimmer, Philipp$$b5$$udkfz
000144480 7001_ $$aKazlauskas, Rymantas$$b6
000144480 7001_ $$aGoebel, Catrin$$b7
000144480 7001_ $$aBotrè, Francesco$$b8
000144480 7001_ $$aDiel, Patrick$$b9
000144480 7001_ $$00000-0001-7407-8300$$aParr, Maria Kristina$$b10
000144480 773__ $$0PERI:(DE-600)1458459-1$$a10.1007/s00204-019-02490-x$$gVol. 93, no. 7, p. 1807 - 1816$$n7$$p1807 - 1816$$tArchives of toxicology$$v93$$x1432-0738$$y2019
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