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000144485 1001_ $$00000-0002-2721-2404$$aWard, Heather A$$b0
000144485 245__ $$aGallstones and incident colorectal cancer in a large pan-European cohort study.
000144485 260__ $$aBognor Regis$$bWiley-Liss$$c2019
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000144485 520__ $$aGallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclear whether gallstones are a risk factor for CRC. We examined the association between history of gallstones and CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a prospective cohort of over half a million participants from ten European countries. History of gallstones was assessed at baseline using a self-reported questionnaire. The analytic cohort included 334,986 participants; a history of gallstones was reported by 3,917 men and 19,836 women, and incident CRC was diagnosed among 1,832 men and 2,178 women (mean follow-up: 13.6 years). Hazard ratios (HR) and 95% confidence intervals (CI) for the association between gallstones and CRC were estimated using Cox proportional hazards regression models, stratified by sex, study centre and age at recruitment. The models were adjusted for body mass index, diabetes, alcohol intake and physical activity. A positive, marginally significant association was detected between gallstones and CRC among women in multivariable analyses (HR = 1.14, 95%CI 0.99-1.31, p = 0.077). The relationship between gallstones and CRC among men was inverse but not significant (HR = 0.81, 95%CI 0.63-1.04, p = 0.10). Additional adjustment for details of reproductive history or waist circumference yielded minimal changes to the observed associations. Further research is required to confirm the nature of the association between gallstones and CRC by sex.
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000144485 7001_ $$00000-0003-3347-8249$$aMurphy, Neil$$b1
000144485 7001_ $$aWeiderpass, Elisabete$$b2
000144485 7001_ $$aLeitzmann, Michael F$$b3
000144485 7001_ $$aAglago, Elom$$b4
000144485 7001_ $$aGunter, Marc J$$b5
000144485 7001_ $$aFreisling, Heinz$$b6
000144485 7001_ $$aJenab, Mazda$$b7
000144485 7001_ $$aBoutron-Ruault, Marie-Christine$$b8
000144485 7001_ $$aSeveri, Gianluca$$b9
000144485 7001_ $$aCarbonnel, Franck$$b10
000144485 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b11$$udkfz
000144485 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b12$$udkfz
000144485 7001_ $$aBoeing, Heiner$$b13
000144485 7001_ $$aTjønneland, Anne$$b14
000144485 7001_ $$aOlsen, Anja$$b15
000144485 7001_ $$aOvervad, Kim$$b16
000144485 7001_ $$aMerino, Susana$$b17
000144485 7001_ $$00000-0002-6236-6804$$aZamora-Ros, Raul$$b18
000144485 7001_ $$aRodríguez-Barranco, Miguel$$b19
000144485 7001_ $$aDorronsoro, Miren$$b20
000144485 7001_ $$aChirlaque, Maria-Dolores$$b21
000144485 7001_ $$aBarricarte, Aurelio$$b22
000144485 7001_ $$aPerez-Cornago, Aurora$$b23
000144485 7001_ $$aTrichopoulou, Antonia$$b24
000144485 7001_ $$00000-0002-3646-8006$$aBamia, Christina$$b25
000144485 7001_ $$aLagiou, Pagona$$b26
000144485 7001_ $$aMasala, Giovanna$$b27
000144485 7001_ $$aGrioni, Sara$$b28
000144485 7001_ $$aTumino, Rosario$$b29
000144485 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b30
000144485 7001_ $$aMattiello, Amalia$$b31
000144485 7001_ $$aBueno-de-Mesquita, Bas$$b32
000144485 7001_ $$aVermeulen, Roel$$b33
000144485 7001_ $$aVan Gils, Carla$$b34
000144485 7001_ $$aNyström, Hanna$$b35
000144485 7001_ $$aRutegård, Martin$$b36
000144485 7001_ $$aAune, Dagfinn$$b37
000144485 7001_ $$aRiboli, Elio$$b38
000144485 7001_ $$aCross, Amanda J$$b39
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