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@ARTICLE{Thielmann:144525,
      author       = {C. M. Thielmann and M. Costa da Silva$^*$ and T. Muley and
                      M. Meister and E. Herpel and M. U. Muckenthaler},
      title        = {{I}ron accumulation in tumor-associated macrophages marks
                      an improved overall survival in patients with lung
                      adenocarcinoma.},
      journal      = {Scientific reports},
      volume       = {9},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2019-01973},
      pages        = {11326},
      year         = {2019},
      abstract     = {Iron-loaded tumor-associated macrophages (iTAMs) show a
                      pro-inflammatory phenotype, hallmarked by anti-tumorigenic
                      activity and an ability to attenuate tumor growth. Here we
                      explored the relevance of these findings in lung cancer
                      patients by investigating the impact of the iTAM content in
                      the tumor microenvironment (TME) on patient survival. We
                      analyzed 102 human non-small cell lung cancer (NSCLC)
                      paraffin-embedded archival tissue samples for iron levels
                      and macrophage numbers. Interestingly, patients with lung
                      adenocarcinoma accumulating iron in the TME show higher
                      numbers of M1-like pro-inflammatory TAMs and a survival
                      advantage compared to iron-negative patients. By contrast,
                      in patients with lung squamous cell carcinoma iron in the
                      TME does not affect survival, suggesting a unique influence
                      of iron on different histological subtypes of non-small cell
                      lung cancer (NSCLC). We conclude that in lung adenocarcinoma
                      iron may serve as a prognostic marker for patient survival
                      and as a potential therapeutic target for anti-cancer
                      therapy.},
      cin          = {D080},
      ddc          = {600},
      cid          = {I:(DE-He78)D080-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31383898},
      pmc          = {pmc:PMC6683135},
      doi          = {10.1038/s41598-019-47833-x},
      url          = {https://inrepo02.dkfz.de/record/144525},
}