%0 Journal Article
%A Huang, Lei
%A Jansen, Lina
%A Balavarca, Yesilda
%A van der Geest, Lydia
%A Lemmens, Valery
%A Groot Koerkamp, Bas
%A van Santvoort, Hjalmar C
%A Grützmann, Robert
%A Besselink, Marc G
%A Schrotz-King, Petra
%A Brenner, Hermann
%T Significance of Examined Lymph Node Number in Accurate Staging and Long-term Survival in Resected Stage I-II Pancreatic Cancer-More is Better? A Large International Population-based Cohort Study.
%J Annals of surgery
%V 274
%N 6
%@ 0003-4932
%C [S.l.]
%I Ovid38850
%M DKFZ-2019-02011
%P e554-e563
%D 2021
%Z 2021 Dec 1;274(6):e554-e563 / #EA:C070#LA:C070#
%X This large international cohort study aimed to investigate the associations of examined lymph node (ELN) number with accurate staging and long-term survival in pancreatic adenocarcinoma (PaC) and to robustly determine the minimal and optimal ELN thresholds.ELN number is an important quality metric in cancer care. The recommended minimal ELN number in PaC to accurately stage cancer varies greatly across guidelines, and the optimal number especially to adequately stratify patient survival has not yet been established.Population-based data on patients with stage I to II PaC resected in 2003 to 2015 from the US Surveillance, Epidemiology, and End Results (SEER)-18 Program and Netherlands National Cancer Registry (NCR) were analyzed. Associations of ELN number with stage migration and survival were evaluated using multivariable-adjusted logistic and Cox regression models, respectively. The series of odds ratios (ORs) for negative-to-positive node stage migration and hazard ratios (HRs) for survival with more ELNs were fitted using a LOWESS smoother, and structural breakpoints were determined by Chow test.Overall 16,241 patients were analyzed. With increasing ELN number, both cohorts exhibited significant proportional increases from node-negative to node-positive disease [ORSEER-18=1.05, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31425290
%R 10.1097/SLA.0000000000003558
%U https://inrepo02.dkfz.de/record/144568