Home > Publications database > Absence of disruptive TP53 mutations in high-risk human papillomavirus-driven neck squamous cell carcinoma of unknown primary. > print

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024 7 _ |a 10.1002/hed.25915
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024 7 _ |a 0148-6403
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024 7 _ |a 1043-3074
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024 7 _ |a 1097-0347
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024 7 _ |a 1930-2398
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037 _ _ |a DKFZ-2019-02023
041 _ _ |a eng
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100 1 _ |a Boscolo-Rizzo, Paolo
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245 _ _ |a Absence of disruptive TP53 mutations in high-risk human papillomavirus-driven neck squamous cell carcinoma of unknown primary.
260 _ _ |a New York, NY [u.a.]
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|b Wiley Interscience
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500 _ _ |a Head Neck. 2019 Nov;41(11):3833-3841
520 _ _ |a To enforce the evidence for causality between high-risk human papillomavirus (hrHPV) infections and neck squamous cell carcinoma from unknown primary (NSCCUP) and provide biological basis for treatment de-intensification, we searched for TP53 mutations in association with HPV status.TP53 mutations were searched for by amplification of exons 4 to 10.Of the 70 NSCCUP, 27 (39%) harbored HPV infection. TP53 sequencing resulted in the identification of 19 patients harboring single mutations including 16 disruptive alterations (84%). The association of TP53 mutations and HPV could be evaluated in 48 NSCCUP including those with disruptive mutation in any exon (n = 16) and those without mutations but with complete sequence of exons 4 to 9 (n = 32): no disruptive mutations were found in the 17 HPV-driven NSCCUP but in 16 of the 31 non-HPV-driven NSCCUP (P = .0002).In a fraction of cases, NSCCUP is an HPV-driven entity harboring wild-type TP53 gene or nondisruptive TP53 mutations. HPV-driven NSCCUP might benefit from treatment de-intensification.
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700 1 _ |a Da Mosto, Maria Cristina
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700 1 _ |a Dal Cin, Elisa
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700 1 _ |a Del Mistro, Annarosa
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700 1 _ |a Quer, Miquel
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700 1 _ |a Polesel, Jerry
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700 1 _ |a Pawlita, Michael
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