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000144594 0247_ $$2doi$$a10.1002/gepi.22242
000144594 0247_ $$2pmid$$apmid:31407831
000144594 0247_ $$2ISSN$$a0741-0395
000144594 0247_ $$2ISSN$$a1098-2272
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000144594 041__ $$aeng
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000144594 1001_ $$aDin, Lennox$$b0
000144594 245__ $$aGenetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
000144594 260__ $$aNew York, NY$$bWiley-Liss$$c2019
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000144594 500__ $$aGenet Epidemiol. 2019 Oct;43(7):844-863
000144594 520__ $$aEpidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)'diseasome', (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.
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000144594 7001_ $$aSheikh, Mohammad$$b1
000144594 7001_ $$aKosaraju, Nikitha$$b2
000144594 7001_ $$aSmedby, Karin Ekstrom$$b3
000144594 7001_ $$aBernatsky, Sasha$$b4
000144594 7001_ $$aBerndt, Sonja I$$b5
000144594 7001_ $$aSkibola, Christine F$$b6
000144594 7001_ $$aNieters, Alexandra$$b7
000144594 7001_ $$aWang, Sophia$$b8
000144594 7001_ $$aMcKay, James D$$b9
000144594 7001_ $$aCocco, Pierluigi$$b10
000144594 7001_ $$aMaynadié, Marc$$b11
000144594 7001_ $$aForetová, Lenka$$b12
000144594 7001_ $$aStaines, Anthony$$b13
000144594 7001_ $$aMack, Thomas M$$b14
000144594 7001_ $$ade Sanjosé, Silvia$$b15
000144594 7001_ $$aVyse, Timothy J$$b16
000144594 7001_ $$aPadyukov, Leonid$$b17
000144594 7001_ $$aMonnereau, Alain$$b18
000144594 7001_ $$aArslan, Alan A$$b19
000144594 7001_ $$aMoore, Amy$$b20
000144594 7001_ $$aBrooks-Wilson, Angela R$$b21
000144594 7001_ $$aNovak, Anne J$$b22
000144594 7001_ $$aGlimelius, Bengt$$b23
000144594 7001_ $$aBirmann, Brenda M$$b24
000144594 7001_ $$aLink, Brian K$$b25
000144594 7001_ $$aStewart, Carolyn$$b26
000144594 7001_ $$aVajdic, Claire M$$b27
000144594 7001_ $$aHaioun, Corinne$$b28
000144594 7001_ $$aMagnani, Corrado$$b29
000144594 7001_ $$aConti, David V$$b30
000144594 7001_ $$aCox, David G$$b31
000144594 7001_ $$aCasabonne, Delphine$$b32
000144594 7001_ $$aAlbanes, Demetrius$$b33
000144594 7001_ $$aKane, Eleanor$$b34
000144594 7001_ $$aRoman, Eve$$b35
000144594 7001_ $$aMuzi, Giacomo$$b36
000144594 7001_ $$aSalles, Gilles$$b37
000144594 7001_ $$aGiles, Graham G$$b38
000144594 7001_ $$aAdami, Hans-Olov$$b39
000144594 7001_ $$aGhesquières, Hervé$$b40
000144594 7001_ $$aDe Vivo, Immaculata$$b41
000144594 7001_ $$aClavel, Jacqueline$$b42
000144594 7001_ $$00000-0002-7482-178X$$aCerhan, James R$$b43
000144594 7001_ $$aSpinelli, John J$$b44
000144594 7001_ $$aHofmann, Jonathan$$b45
000144594 7001_ $$aVijai, Joseph$$b46
000144594 7001_ $$aCurtin, Karen$$b47
000144594 7001_ $$aCostenbader, Karen H$$b48
000144594 7001_ $$aOnel, Kenan$$b49
000144594 7001_ $$aOffit, Kenneth$$b50
000144594 7001_ $$aTeras, Lauren R$$b51
000144594 7001_ $$aMorton, Lindsay$$b52
000144594 7001_ $$aConde, Lucia$$b53
000144594 7001_ $$aMiligi, Lucia$$b54
000144594 7001_ $$aMelbye, Mads$$b55
000144594 7001_ $$aEnnas, Maria Grazia$$b56
000144594 7001_ $$aLiebow, Mark$$b57
000144594 7001_ $$aPurdue, Mark P$$b58
000144594 7001_ $$aGlenn, Martha$$b59
000144594 7001_ $$aSouthey, Melissa C$$b60
000144594 7001_ $$aDin, Morris$$b61
000144594 7001_ $$aRothman, Nathaniel$$b62
000144594 7001_ $$aCamp, Nicola J$$b63
000144594 7001_ $$aWong Doo, Nicole$$b64
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000144594 7001_ $$aPradhan, Nisha$$b66
000144594 7001_ $$aBracci, Paige M$$b67
000144594 7001_ $$aBoffetta, Paolo$$b68
000144594 7001_ $$aVineis, Paolo$$b69
000144594 7001_ $$aBrennan, Paul$$b70
000144594 7001_ $$aKraft, Peter$$b71
000144594 7001_ $$aLan, Qing$$b72
000144594 7001_ $$aSeverson, Richard K$$b73
000144594 7001_ $$aVermeulen, Roel C H$$b74
000144594 7001_ $$aMilne, Roger L$$b75
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000144594 7001_ $$aTravis, Ruth C$$b77
000144594 7001_ $$aWeinstein, Stephanie J$$b78
000144594 7001_ $$aChanock, Stephen J$$b79
000144594 7001_ $$aAnsell, Stephen M$$b80
000144594 7001_ $$aSlager, Susan L$$b81
000144594 7001_ $$aZheng, Tongzhang$$b82
000144594 7001_ $$aZhang, Yawei$$b83
000144594 7001_ $$aBenavente, Yolanda$$b84
000144594 7001_ $$aTaub, Zachary$$b85
000144594 7001_ $$aMadireddy, Lohith$$b86
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000144594 7001_ $$aOksenberg, Jorge R$$b88
000144594 7001_ $$aCozen, Wendy$$b89
000144594 7001_ $$aHjalgrim, Henrik$$b90
000144594 7001_ $$00000-0001-8075-4176$$aKhankhanian, Pouya$$b91
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