TY  - JOUR
AU  - Din, Lennox
AU  - Sheikh, Mohammad
AU  - Kosaraju, Nikitha
AU  - Smedby, Karin Ekstrom
AU  - Bernatsky, Sasha
AU  - Berndt, Sonja I
AU  - Skibola, Christine F
AU  - Nieters, Alexandra
AU  - Wang, Sophia
AU  - McKay, James D
AU  - Cocco, Pierluigi
AU  - Maynadié, Marc
AU  - Foretová, Lenka
AU  - Staines, Anthony
AU  - Mack, Thomas M
AU  - de Sanjosé, Silvia
AU  - Vyse, Timothy J
AU  - Padyukov, Leonid
AU  - Monnereau, Alain
AU  - Arslan, Alan A
AU  - Moore, Amy
AU  - Brooks-Wilson, Angela R
AU  - Novak, Anne J
AU  - Glimelius, Bengt
AU  - Birmann, Brenda M
AU  - Link, Brian K
AU  - Stewart, Carolyn
AU  - Vajdic, Claire M
AU  - Haioun, Corinne
AU  - Magnani, Corrado
AU  - Conti, David V
AU  - Cox, David G
AU  - Casabonne, Delphine
AU  - Albanes, Demetrius
AU  - Kane, Eleanor
AU  - Roman, Eve
AU  - Muzi, Giacomo
AU  - Salles, Gilles
AU  - Giles, Graham G
AU  - Adami, Hans-Olov
AU  - Ghesquières, Hervé
AU  - De Vivo, Immaculata
AU  - Clavel, Jacqueline
AU  - Cerhan, James R
AU  - Spinelli, John J
AU  - Hofmann, Jonathan
AU  - Vijai, Joseph
AU  - Curtin, Karen
AU  - Costenbader, Karen H
AU  - Onel, Kenan
AU  - Offit, Kenneth
AU  - Teras, Lauren R
AU  - Morton, Lindsay
AU  - Conde, Lucia
AU  - Miligi, Lucia
AU  - Melbye, Mads
AU  - Ennas, Maria Grazia
AU  - Liebow, Mark
AU  - Purdue, Mark P
AU  - Glenn, Martha
AU  - Southey, Melissa C
AU  - Din, Morris
AU  - Rothman, Nathaniel
AU  - Camp, Nicola J
AU  - Wong Doo, Nicole
AU  - Becker, Nikolaus
AU  - Pradhan, Nisha
AU  - Bracci, Paige M
AU  - Boffetta, Paolo
AU  - Vineis, Paolo
AU  - Brennan, Paul
AU  - Kraft, Peter
AU  - Lan, Qing
AU  - Severson, Richard K
AU  - Vermeulen, Roel C H
AU  - Milne, Roger L
AU  - Kaaks, Rudolf
AU  - Travis, Ruth C
AU  - Weinstein, Stephanie J
AU  - Chanock, Stephen J
AU  - Ansell, Stephen M
AU  - Slager, Susan L
AU  - Zheng, Tongzhang
AU  - Zhang, Yawei
AU  - Benavente, Yolanda
AU  - Taub, Zachary
AU  - Madireddy, Lohith
AU  - Gourraud, Pierre-Antoine
AU  - Oksenberg, Jorge R
AU  - Cozen, Wendy
AU  - Hjalgrim, Henrik
AU  - Khankhanian, Pouya
TI  - Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
JO  - Genetic epidemiology
VL  - 43
IS  - 7
SN  - 1098-2272
CY  - New York, NY
PB  - Wiley-Liss
M1  - DKFZ-2019-02036
SP  - 844-863
PY  - 2019
N1  - Genet Epidemiol. 2019 Oct;43(7):844-863
AB  - Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)'diseasome', (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.
LB  - PUB:(DE-HGF)16
C6  - pmid:31407831
DO  - DOI:10.1002/gepi.22242
UR  - https://inrepo02.dkfz.de/record/144594
ER  -