%0 Journal Article
%A Kühn, Tilman
%A Stepien, Magdalena
%A López-Nogueroles, Marina
%A Machado, Antje Damms
%A Sookthai, Disorn
%A Johnson, Theron
%A Roca, Marta
%A Hüsing, Anika
%A Maldonado, Sandra González
%A Cross, Amanda J
%A Murphy, Neil
%A Freisling, Heinz
%A Rinaldi, Sabina
%A Scalbert, Augustin
%A Fedirco, Veronika
%A Severi, Gianluca
%A Boutron-Ruault, Marie-Christine
%A Mancini, Francesca Romana
%A Sowah, Solomon A
%A Boeing, Heiner
%A Jakszyn, Paula
%A Sánchez, Maria-Jose
%A Merino, Susana
%A Colorado-Yohar, Sandra
%A Barricarte, Aurelio
%A Khaw, Kay Tee
%A Schmidt, Julie A
%A Perez-Cornago, Aurora
%A Trichopoulou, Antonia
%A Karakatsani, Anna
%A Thriskos, Paschalis
%A Palli, Domenico
%A Agnoli, Claudia
%A Tumino, Rosario
%A Sacerdote, Carlotta
%A Panico, Salvatore
%A Bueno-de-Mesquita, Bas
%A van Gils, Carla H
%A Heath, Alicia
%A Gunter, Marc J
%A Riboli, Elio
%A Lahoz, Agustín
%A Jenab, Mazda
%A Kaaks, Rudolf
%T Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study.
%J Journal of the National Cancer Institute
%V 112
%N 5
%@ 1460-2105
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2019-02077
%P 516-524
%D 2020
%Z 2020 May 1;112(5):516-524#EA:C020#LA:C020#
%X Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans.Associations between pre-diagnostic plasma levels of 17 primary, secondary and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations.Positive associations were observed between colon cancer risk and plasma levels of 7 conjugated bile acid metabolites, i.e. primary bile acids glycocholic acid (ORQuartile 4 vs. Quartile 1=2.22,95 
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31435679
%R 10.1093/jnci/djz166
%U https://inrepo02.dkfz.de/record/144635