TY  - JOUR
AU  - Kühn, Tilman
AU  - Stepien, Magdalena
AU  - López-Nogueroles, Marina
AU  - Machado, Antje Damms
AU  - Sookthai, Disorn
AU  - Johnson, Theron
AU  - Roca, Marta
AU  - Hüsing, Anika
AU  - Maldonado, Sandra González
AU  - Cross, Amanda J
AU  - Murphy, Neil
AU  - Freisling, Heinz
AU  - Rinaldi, Sabina
AU  - Scalbert, Augustin
AU  - Fedirco, Veronika
AU  - Severi, Gianluca
AU  - Boutron-Ruault, Marie-Christine
AU  - Mancini, Francesca Romana
AU  - Sowah, Solomon A
AU  - Boeing, Heiner
AU  - Jakszyn, Paula
AU  - Sánchez, Maria-Jose
AU  - Merino, Susana
AU  - Colorado-Yohar, Sandra
AU  - Barricarte, Aurelio
AU  - Khaw, Kay Tee
AU  - Schmidt, Julie A
AU  - Perez-Cornago, Aurora
AU  - Trichopoulou, Antonia
AU  - Karakatsani, Anna
AU  - Thriskos, Paschalis
AU  - Palli, Domenico
AU  - Agnoli, Claudia
AU  - Tumino, Rosario
AU  - Sacerdote, Carlotta
AU  - Panico, Salvatore
AU  - Bueno-de-Mesquita, Bas
AU  - van Gils, Carla H
AU  - Heath, Alicia
AU  - Gunter, Marc J
AU  - Riboli, Elio
AU  - Lahoz, Agustín
AU  - Jenab, Mazda
AU  - Kaaks, Rudolf
TI  - Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study.
JO  - Journal of the National Cancer Institute
VL  - 112
IS  - 5
SN  - 1460-2105
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2019-02077
SP  - 516-524
PY  - 2020
N1  - 2020 May 1;112(5):516-524#EA:C020#LA:C020#
AB  - Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans.Associations between pre-diagnostic plasma levels of 17 primary, secondary and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations.Positive associations were observed between colon cancer risk and plasma levels of 7 conjugated bile acid metabolites, i.e. primary bile acids glycocholic acid (ORQuartile 4 vs. Quartile 1=2.22,95 
LB  - PUB:(DE-HGF)16
C6  - pmid:31435679
DO  - DOI:10.1093/jnci/djz166
UR  - https://inrepo02.dkfz.de/record/144635
ER  -