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@ARTICLE{Khn:144635,
      author       = {T. Kühn$^*$ and M. Stepien and M. López-Nogueroles and A.
                      D. Machado$^*$ and D. Sookthai$^*$ and T. Johnson$^*$ and M.
                      Roca and A. Hüsing$^*$ and S. G. Maldonado and A. J. Cross
                      and N. Murphy and H. Freisling and S. Rinaldi and A.
                      Scalbert and V. Fedirco and G. Severi and M.-C.
                      Boutron-Ruault and F. R. Mancini and S. A. Sowah$^*$ and H.
                      Boeing and P. Jakszyn and M.-J. Sánchez and S. Merino and
                      S. Colorado-Yohar and A. Barricarte and K. T. Khaw and J. A.
                      Schmidt and A. Perez-Cornago and A. Trichopoulou and A.
                      Karakatsani and P. Thriskos and D. Palli and C. Agnoli and
                      R. Tumino and C. Sacerdote and S. Panico and B.
                      Bueno-de-Mesquita and C. H. van Gils and A. Heath and M. J.
                      Gunter and E. Riboli and A. Lahoz and M. Jenab and R.
                      Kaaks$^*$},
      title        = {{P}re-diagnostic plasma bile acid levels and colon cancer
                      risk: {A} prospective study.},
      journal      = {Journal of the National Cancer Institute},
      volume       = {112},
      number       = {5},
      issn         = {1460-2105},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2019-02077},
      pages        = {516-524},
      year         = {2020},
      note         = {2020 May 1;112(5):516-524#EA:C020#LA:C020#},
      abstract     = {Bile acids have been proposed to promote colon
                      carcinogenesis. However, there are limited prospective data
                      on circulating bile acid levels and colon cancer risk in
                      humans.Associations between pre-diagnostic plasma levels of
                      17 primary, secondary and tertiary bile acid metabolites
                      (conjugated and unconjugated) and colon cancer risk were
                      evaluated in a nested case-control study within the European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      cohort. Bile acid levels were quantified by tandem mass
                      spectrometry in samples from 569 incident colon cancer cases
                      and 569 matched controls. Multivariable logistic regression
                      analyses were used to estimate odds ratios (ORs) for colon
                      cancer risk across quartiles of bile acid
                      concentrations.Positive associations were observed between
                      colon cancer risk and plasma levels of 7 conjugated bile
                      acid metabolites, i.e. primary bile acids glycocholic acid
                      (ORQuartile 4 vs. Quartile 1=2.22,95 $\%$ confidence
                      interval[CI]=1.52, 3.26), taurocholic acid (OR = 1.78,
                      $95\%CI=1.23,$ 2.58), glycochenodeoxycholic acid
                      (OR = 1.68, $95\%CI=1.13,$ 2.48), taurochenodeoxycholic
                      acid (OR = 1.62, $95\%CI=1.11-2.36),$ and glycohyocholic
                      acid (OR = 1.65, $95\%CI=1.13,$ 2.40) as well as the
                      secondary bile acids glycodeoxycholic acid (OR = 1.68,
                      $95\%CI=1.12,$ 2.54) and taurodeoxycholic acid
                      (OR = 1.54, $95\%CI=1.02,$ 2.31). By contrast,
                      unconjugated bile acids and tertiary bile acids were not
                      associated with risk.This prospective study showed that
                      pre-diagnostic levels of certain conjugated primary and
                      secondary bile acids were positively associated with risk of
                      colon cancer. Our findings support experimental data to
                      suggest that a high bile acid load is colon cancer
                      promotive.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31435679},
      doi          = {10.1093/jnci/djz166},
      url          = {https://inrepo02.dkfz.de/record/144635},
}