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000144648 1001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b0$$eFirst author
000144648 245__ $$aQuality of Life, Fatigue, and Sleep Problems in Pancreatic Cancer Patients - A Randomized Trial on the Effects of Exercise
000144648 260__ $$aKöln$$bDt. Ärzte-Verl.$$c2019
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000144648 520__ $$aImproving quality of life (QoL) is an important treatment goal in pancreatic cancer patients. Although the beneficial effects of exercise on QoL are well understood, few studies have investigated more aggressive cancers such as pancreatic cancer.Within a randomized trial, we assessed the efficacy of 6-month resistance training on physical functioning (primary outcome) and further QoL-related outcomes. 65 pancreatic cancer patients were assigned to home-based training, supervised training, or a usual care control group. Analysis-of-covariance models on changes from baseline to 6 and 3 months were ap- plied.47 patients completed the intervention period. After 6 months, no effects of resistance training were observed. However, after 3 months, explorative analyses showed significant between-group mean differences (MD) in favor for resistance training for physical functioning (pooled group: MD=11.0; p=0.016; effect size[ES]=0.31), as well as for global QoL (MD=12.1; p=0.016; effect size=0.56), and other outcomes, such as sleep problems and fatigue. Multiple imputation analyses yielded similar results. Home-based and supervised training performed similarly.This first randomized resistance training trial in pancreatic cancer patients indicated clinically relevant improve- ments in QoL after 3 but not after 6 months. Given the severity of pancreatic cancer, exercise recommendations may already commence at surgery.
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000144648 7001_ $$0P:(DE-He78)f52b77d7ab843c9b900134aafc61638a$$aClauss, Dorothea$$b1$$eFirst author
000144648 7001_ $$aTjaden, Christine$$b2
000144648 7001_ $$aHackert, Thilo$$b3
000144648 7001_ $$0P:(DE-He78)63e25168359ecc68156e34417d75d0a7$$aHerbolsheimer, Florian$$b4$$udkfz
000144648 7001_ $$aBruckner, Thomas$$b5
000144648 7001_ $$aSchneider, Lutz$$b6
000144648 7001_ $$aUlrich, Cornelia M$$b7
000144648 7001_ $$0P:(DE-He78)60b584aeef81e4c57fd111fa63779b73$$aWiskemann, Joachim$$b8
000144648 773__ $$0PERI:(DE-600)2406159-1$$a10.3238/arztebl.2019.0471$$gVol. 116, no. 27-28$$n27-28$$p471-478$$tDeutsches Ärzteblatt international$$v116$$x1866-0452$$y2019
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