TY  - JOUR
AU  - Selby, Kevin
AU  - Levine, Emma H
AU  - Doan, Cecilia
AU  - Gies, Anton
AU  - Brenner, Hermann
AU  - Quesenberry, Charles
AU  - Lee, Jeffrey K
AU  - Corley, Douglas A
TI  - Effect of Sex, Age and Positivity Threshold on Fecal Immunochemical Test Accuracy: a Systematic Review and Meta-Analysis.
JO  - Gastroenterology
VL  - 157
IS  - 6
SN  - 0016-5085
CY  - Philadelphia, Pa. [u.a.]
PB  - Saunders
M1  - DKFZ-2019-02126
SP  - 1494-1505
PY  - 2019
N1  - 157(6):1494-1505
AB  - Quantitative fecal immunochemical tests (FITs) for hemoglobin are commonly used for colorectal cancer (CRC) screening. We aimed to quantify the change in CRC and advanced adenoma detection and number of positive test results at different positivity thresholds and by sex and age.We searched MEDLINE and EMBASE, selecting articles of FIT for CRC detection in asymptomatic adults undergoing screening. We calculated sensitivity and specificity, as well as detected number of cancers, advanced adenomas, and positive test results at positivity thresholds ≤10 μg hemoglobin/g feces, 10 to ≤20 μg/g, 20 to ≤30 μg/g, and >30 μg/g. We also analyzed results from stratified by patient sex, age, and reference standard.Our meta-analysis comprised 46 studies with 2.4 million participants and 6478 detected cancers. Sensitivity for detection of CRC increased from 69
LB  - PUB:(DE-HGF)16
C6  - pmid:31472152
DO  - DOI:10.1053/j.gastro.2019.08.023
UR  - https://inrepo02.dkfz.de/record/144684
ER  -