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@ARTICLE{deRojas:144697,
      author       = {T. de Rojas and B. Kasper and W. Van der Graaf and S. M.
                      Pfister$^*$ and F. Bielle and T. Ribalta and P. Shenjere and
                      M. Preusser and S. Fröhling$^*$ and V. Golfinopoulos and M.
                      Morfouace and M. G. McCabe},
      title        = {{EORTC} {SPECTA}-{AYA}: {A} unique molecular profiling
                      platform for adolescents and young adults with cancer in
                      {E}urope.},
      journal      = {International journal of cancer},
      volume       = {147},
      number       = {4},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2019-02139},
      pages        = {1180-1184},
      year         = {2020},
      note         = {2020 Aug 15;147(4):1180-1184},
      abstract     = {For most adolescent and young adult (AYA) cancers,
                      age-specific molecular features are poorly understood.
                      SPECTA, an academic translational research infrastructure
                      for biomaterial collection, will explicitly recruit AYA
                      patients and will therefore collect empirical data to bridge
                      the molecular gap between pediatric and adult oncology. The
                      initial pilot study, activated in Feb-2019 across Europe,
                      will recruit 100 AYA patients (aged 12-29 years) with
                      newly diagnosed or relapsed high-grade gliomas and
                      high-grade bone and soft tissue sarcomas. The primary
                      objective of the pilot is to determine feasibility and
                      recruitment rates. Formalin-fixed tumor tissue and whole
                      blood from study participants will be prospectively
                      collected with clinical data and stored centrally at the
                      Integrated BioBank of Luxembourg (IBBL). Whole exome
                      sequencing (WES) of matched tumor and blood, and tumor RNA
                      sequencing and DNA methylation profiling will be performed
                      at the German Cancer Research Center (DKFZ), Heidelberg.
                      Virtual central pathology review of scanned diagnostic
                      slides will be undertaken by an international expert panel,
                      and diagnostic material returned to the participating
                      centers. A multidisciplinary molecular tumor board will
                      release a clinically validated report to referring
                      clinicians within 4-6 weeks after biopsy. SPECTA-AYA
                      constitutes a major opportunity to gain knowledge about the
                      tumor biology of this unique age group. It incorporates
                      notable innovative aspects: AYA specificity, pan-European
                      academic collaboration, centralized biobanking,
                      comprehensive molecular profiling, and virtual central
                      pathology review, among others. SPECTA-AYA will help
                      untangle the tumor particularities of AYAs with cancer and
                      aims to improve their access to novel drugs and personalized
                      medicine. This article is protected by copyright. All rights
                      reserved.},
      cin          = {B062 / B340 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B340-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31465545},
      doi          = {10.1002/ijc.32651},
      url          = {https://inrepo02.dkfz.de/record/144697},
}