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@ARTICLE{Grafetsttter:144752,
      author       = {M. Grafetstätter$^*$ and L. Pletsch-Borba$^*$ and D.
                      Sookthai$^*$ and N. Karavasiloglou and T. Johnson$^*$ and V.
                      A. Katzke$^*$ and M. Hoffmeister$^*$ and P. Bugert and R.
                      Kaaks$^*$ and T. Kühn$^*$},
      title        = {{T}hrombomodulin and {T}hrombopoietin, {T}wo {B}iomarkers
                      of {H}emostasis, {A}re {P}ositively {A}ssociated with
                      {A}dherence to the {W}orld {C}ancer {R}esearch
                      {F}und/{A}merican {I}nstitute for {C}ancer {R}esearch
                      {R}ecommendations for {C}ancer {P}revention in a
                      {P}opulation-{B}ased {C}ross-{S}ectional {S}tudy.},
      journal      = {Nutrients},
      volume       = {11},
      number       = {9},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2019-02184},
      pages        = {2067},
      year         = {2019},
      abstract     = {A pro-coagulative state is related to increased risk of
                      cardiovascular diseases but also certain cancers. Since
                      experimental and smaller human studies suggest that diet,
                      physical activity, and body weight may all affect
                      coagulation, we evaluated associations between these
                      lifestyle factors and hemostatic biomarkers in a
                      population-based study. Cross-sectional baseline data from
                      2267 randomly selected participants of EPIC-Heidelberg (age
                      range 35-65 years) was used. Fibrinogen, glycoprotein
                      IIb/IIIa, P-selectin, thrombomodulin (TM), and
                      thrombopoietin (TPO) were measured in baseline plasma
                      samples. A score reflecting adherence to the World Cancer
                      Research Fund/American Institute for Cancer Research
                      (WCRF/AICR) recommendations for cancer prevention was
                      created. Associations between the WCRF/AICR score as well as
                      its individual components and hemostatic biomarkers were
                      analyzed by linear regression models. Multivariable-adjusted
                      geometric means $(95\%$ confidence intervals) of TM and TPO
                      were higher with greater adherence to the WCRF/AICR
                      recommendations (TM, lowest vs. highest score category: 2.90
                      (2.7,3.1) vs. 3.10 (2.9,3.3) ng/mL, plinear trend = 0.0001;
                      TPO: 328 (302,356) vs. 348 (321,378) pg/mL, plinear trend =
                      0.0007). These associations were driven by lower alcohol and
                      meat consumption among persons with higher WCRF/AICR scores.
                      Our results indicate that lifestyle factors favorably affect
                      TM and TPO, two hemostatic factors implicated in chronic
                      disease development.},
      cin          = {C020 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31484340},
      doi          = {10.3390/nu11092067},
      url          = {https://inrepo02.dkfz.de/record/144752},
}