TY  - JOUR
AU  - Weigl, Korbinian
AU  - Chang-Claude, Jenny
AU  - Hsu, Li
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Establishing a valid approach for estimating familial risk of cancer explained by common genetic variants.
JO  - International journal of cancer
VL  - 146
IS  - 1
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2019-02185
SP  - 68-75
PY  - 2020
N1  - 146(1):68-75#EA:C070#LA:C070#
AB  - We critically examined existing approaches for the estimation of the excess familial risk of cancer which can be attributed to identified common genetic risk variants and propose an alternative, more straightforward approach for calculating this proportion using well-established epidemiological methodology. We applied the underlying equations of the traditional approaches and the new epidemiological approach for colorectal cancer (CRC) in a large population-based case-control study in Germany with 4,447 cases and 3,480 controls, who were recruited from 2003 to 2016 and for whom interview, medical and genomic data were available. Having a family history of CRC (FH) was associated with a 1.77-fold risk increase in our study population (95
LB  - PUB:(DE-HGF)16
C6  - pmid:31483856
DO  - DOI:10.1002/ijc.32664
UR  - https://inrepo02.dkfz.de/record/144753
ER  -