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@ARTICLE{Javelle:144814,
      author       = {F. Javelle and A. Lampit and W. Bloch and P. Häussermann
                      and S. L. Johnson and P. Zimmer$^*$},
      title        = {{E}ffects of 5-hydroxytryptophan on distinct types of
                      depression: a systematic review and meta-analysis.},
      journal      = {Nutrition reviews},
      volume       = {78},
      number       = {1},
      issn         = {1753-4887},
      address      = {Lawrence, Kan.},
      publisher    = {Internat. Life Sciences Inst.},
      reportid     = {DKFZ-2019-02239},
      pages        = {77-88},
      year         = {2020},
      note         = {2020 Jan 1;78(1):77-88#LA:C110#},
      abstract     = {Serotonergic dysfunction, including reduced central
                      serotonin levels, is associated with different psychiatric
                      syndromes, including depression. As a serotonin precursor,
                      5-hydroxytryptophan has long been used as a
                      nonpharmacological treatment for depression.A systematic
                      review and meta-analysis was conducted to determine the
                      antidepressant effects of 5-hydroxytryptophan in depressed
                      patients.MEDLINE (via PubMed) and Google Scholar were
                      searched from inception to May 2018.Thirteen investigations
                      were included in the systematic review (using PRISMA
                      guidelines), and 7 in the full meta-analysis (pre-registered
                      on PROSPERO: CRD42018104415).Analyses revealed a depression
                      remission rate of 0.65 $(95\%$ confidence interval [CI],
                      0.55-0.78; remission rate [k] = 13), and this was
                      confirmed by the questionnaire results, which revealed a
                      large Hedges' g (1.11; $95\%CI,$ 0.53-1.69). Methodological
                      variability (in treatment duration, type of depression
                      studied, experimental design, 5-hydroxytryptophan dosage)
                      contributes to heterogeneity in the results
                      $(I2 = 76\%,$ τ2 = 0.379). In addition, the OHAT
                      (Office of Health Assessment and Translation risk of bias
                      rating) tool suggested that, on the whole, current studies
                      are relatively weak (few include placebo groups).Further
                      trials should overcome these limitations by using
                      placebo-controlled studies that include patients with
                      well-defined depression diagnoses, along with strong
                      characterization of psychological and physiological patient
                      characteristics.},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31504850},
      doi          = {10.1093/nutrit/nuz039},
      url          = {https://inrepo02.dkfz.de/record/144814},
}