% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Teumer:144824,
      author       = {A. Teumer and Y. Li and S. Ghasemi and B. P. Prins and M.
                      Wuttke and T. Hermle and A. Giri and K. B. Sieber and C. Qiu
                      and H. Kirsten and A. Tin and A. Y. Chu and N. Bansal and M.
                      F. Feitosa and L. Wang and J.-F. Chai and M. Cocca and C.
                      Fuchsberger and M. Gorski and A. Hoppmann and K. Horn and M.
                      Li and J. Marten and D. Noce and T. Nutile and S. Sedaghat
                      and G. Sveinbjornsson and B. O. Tayo and P. J. van der Most
                      and Y. Xu and Z. Yu and L. Gerstner and J. Ärnlöv and S.
                      J. L. Bakker and D. Baptista and M. L. Biggs and E.
                      Boerwinkle and H. Brenner$^*$ and R. Burkhardt and R. J.
                      Carroll and M.-L. Chee and M.-L. Chee and M. Chen and C.-Y.
                      Cheng and J. P. Cook and J. Coresh and T. Corre and J.
                      Danesh and M. H. de Borst and A. De Grandi and R. de Mutsert
                      and A. P. J. de Vries and F. Degenhardt and K. Dittrich and
                      J. Divers and K.-U. Eckardt and G. Ehret and K. Endlich and
                      J. F. Felix and O. H. Franco and A. Franke and B. I.
                      Freedman and S. Freitag-Wolf and R. T. Gansevoort and V.
                      Giedraitis and M. Gögele and F. Grundner-Culemann and D. F.
                      Gudbjartsson and V. Gudnason and P. Hamet and T. B. Harris
                      and A. A. Hicks and H. Holm and V. H. X. Foo and S.-J. Hwang
                      and M. A. Ikram and E. Ingelsson and V. W. V. Jaddoe and J.
                      Jakobsdottir and N. S. Josyula and B. Jung and M. Kähönen
                      and C.-C. Khor and W. Kiess and W. Koenig and A. Körner and
                      P. Kovacs and H. Kramer and B. K. Krämer and F. Kronenberg
                      and L. A. Lange and C. D. Langefeld and J. J. Lee and T.
                      Lehtimäki and W. Lieb and S.-C. Lim and L. Lind and C. M.
                      Lindgren and J. Liu and M. Loeffler and L.-P. Lyytikäinen
                      and A. Mahajan and J. C. Maranville and D. Mascalzoni and B.
                      McMullen and C. Meisinger and T. Meitinger and K. Miliku and
                      D. O. Mook-Kanamori and M. Müller-Nurasyid and J. C.
                      Mychaleckyj and M. Nauck and K. Nikus and B. Ning and R.
                      Noordam and J. O. Connell and I. Olafsson and N. D. Palmer
                      and A. Peters and A. I. Podgornaia and B. Ponte and T.
                      Poulain and P. P. Pramstaller and T. J. Rabelink and L. M.
                      Raffield and D. F. Reilly and R. Rettig and M. Rheinberger
                      and K. M. Rice and F. Rivadeneira and H. Runz and K. A. Ryan
                      and C. Sabanayagam and K.-U. Saum$^*$ and B. Schöttker$^*$
                      and C. M. Shaffer and Y. Shi and A. V. Smith and K. Strauch
                      and M. Stumvoll and B. B. Sun and S. Szymczak and E.-S. Tai
                      and N. Y. Q. Tan and K. D. Taylor and A. Teren and Y.-C.
                      Tham and J. Thiery and C. H. L. Thio and H. Thomsen$^*$ and
                      U. Thorsteinsdottir and A. Tönjes and J. Tremblay and A. G.
                      Uitterlinden and P. van der Harst and N. Verweij and S.
                      Vogelezang and U. Völker and M. Waldenberger and C. Wang
                      and O. D. Wilson and C. Wong and T.-Y. Wong and Q. Yang and
                      M. Yasuda and S. Akilesh and M. Bochud and C. A. Böger and
                      O. Devuyst and T. L. Edwards and K. Ho and A. P. Morris and
                      A. Parsa and S. A. Pendergrass and B. M. Psaty and J. I.
                      Rotter and K. Stefansson and J. G. Wilson and K. Susztak and
                      H. Snieder and I. M. Heid and M. Scholz and A. S.
                      Butterworth and A. M. Hung and C. Pattaro and A. Köttgen},
      title        = {{G}enome-wide association meta-analyses and fine-mapping
                      elucidate pathways influencing albuminuria.},
      journal      = {Nature Communications},
      volume       = {10},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2019-02249},
      pages        = {4130},
      year         = {2019},
      abstract     = {Increased levels of the urinary albumin-to-creatinine ratio
                      (UACR) are associated with higher risk of kidney disease
                      progression and cardiovascular events, but underlying
                      mechanisms are incompletely understood. Here, we conduct
                      trans-ethnic (n = 564,257) and European-ancestry
                      specific meta-analyses of genome-wide association studies of
                      UACR, including ancestry- and diabetes-specific analyses,
                      and identify 68 UACR-associated loci. Genetic correlation
                      analyses and risk score associations in an independent
                      electronic medical records database (n = 192,868) reveal
                      connections with proteinuria, hyperlipidemia, gout, and
                      hypertension. Fine-mapping and trans-Omics analyses with
                      gene expression in 47 tissues and plasma protein levels
                      implicate genes potentially operating through differential
                      expression in kidney (including TGFB1, MUC1, PRKCI, and
                      OAF), and allow coupling of UACR associations to altered
                      plasma OAF concentrations. Knockdown of OAF and PRKCI
                      orthologs in Drosophila nephrocytes reduces albumin
                      endocytosis. Silencing fly PRKCI further impairs slit
                      diaphragm formation. These results generate a priority list
                      of genes and pathways for translational research to reduce
                      albuminuria.},
      cin          = {C070 / C120 / C050},
      ddc          = {500},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)C050-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31511532},
      pmc          = {pmc:PMC6739370},
      doi          = {10.1038/s41467-019-11576-0},
      url          = {https://inrepo02.dkfz.de/record/144824},
}