%0 Journal Article
%A van Vulpen, Jonna K
%A Sweegers, Maike G
%A Peeters, Petra H M
%A Courneya, Kerry S
%A Newton, Robert U
%A Aaronson, Neil K
%A Jacobsen, Paul B
%A Galvão, Daniel A
%A Chinapaw, Mai J
%A Steindorf, Karen
%A Irwin, Melinda L
%A Stuiver, Martijn M
%A Hayes, Sandi
%A Griffith, Kathleen A
%A Mesters, Ilse
%A Knoop, Hans
%A Goedendorp, Martine M
%A Mutrie, Nanette
%A Daley, Amanda J
%A McConnachie, Alex
%A Bohus, Martin
%A Thorsen, Lene
%A Schulz, Karl-Heinz
%A Short, Camille E
%A James, Erica L
%A Plotnikoff, Ronald C
%A Schmidt, Martina E
%A Ulrich, Cornelia M
%A van Beurden, Marc
%A Oldenburg, Hester S
%A Sonke, Gabe S
%A van Harten, Wim H
%A Schmitz, Kathryn H
%A Winters-Stone, Kerri M
%A Velthuis, Miranda J
%A Taaffe, Dennis R
%A van Mechelen, Willem
%A Kersten, Marie José
%A Nollet, Frans
%A Wenzel, Jennifer
%A Wiskemann, Joachim
%A Verdonck-de Leeuw, Irma M
%A Brug, Johannes
%A May, Anne M
%A Buffart, Laurien M
%T Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data.
%J Medicine and science in sports and exercise
%V 52
%N 2
%@ 0195-9131
%C [s.l.]
%I Ovid
%M DKFZ-2019-02256
%P 303-314
%D 2020
%Z 2020 Feb;52(2):303-314
%X Fatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCTs) to investigate moderators of exercise intervention effects on cancer-related fatigue.We used individual patient data from 31 exercise RCTs worldwide, representing 4,366 patients, of whom 3,846 had complete fatigue data. We performed a one-step individual patient data meta-analysis, using linear mixed-effect models to analyze the effects of exercise interventions on fatigue (z-score) and to identify demographic, clinical, intervention- and exercise-related moderators. Models were adjusted for baseline fatigue and included a random intercept on study level to account for clustering of patients within studies. We identified potential moderators by testing their interaction with group allocation, using a likelihood ratio test.Exercise interventions had statistically significant beneficial effects on fatigue (β= -0.17 [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31524827
%R 10.1249/MSS.0000000000002154
%U https://inrepo02.dkfz.de/record/144831