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000144831 041__ $$aeng
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000144831 1001_ $$avan Vulpen, Jonna K$$b0
000144831 245__ $$aModerators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data.
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000144831 500__ $$a2020 Feb;52(2):303-314
000144831 520__ $$aFatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCTs) to investigate moderators of exercise intervention effects on cancer-related fatigue.We used individual patient data from 31 exercise RCTs worldwide, representing 4,366 patients, of whom 3,846 had complete fatigue data. We performed a one-step individual patient data meta-analysis, using linear mixed-effect models to analyze the effects of exercise interventions on fatigue (z-score) and to identify demographic, clinical, intervention- and exercise-related moderators. Models were adjusted for baseline fatigue and included a random intercept on study level to account for clustering of patients within studies. We identified potential moderators by testing their interaction with group allocation, using a likelihood ratio test.Exercise interventions had statistically significant beneficial effects on fatigue (β= -0.17 [95% confidence interval (CI) -0.22;-0.12]). There was no evidence of moderation by demographic or clinical characteristics. Supervised exercise interventions had significantly larger effects on fatigue than unsupervised exercise interventions (βdifference= -0.18 [95%CI -0.28;-0.08]). Supervised interventions with a duration ≤12 weeks showed larger effects on fatigue (β= -0.29 [95% CI -0.39;-0.20]) than supervised interventions with a longer duration. Conclusions - In this individual patient data meta-analysis, we found statistically significant beneficial effects of exercise interventions on fatigue, irrespective of demographic and clinical characteristics. These findings support a role for exercise, preferably supervised exercise interventions, in clinical practice. Reasons for differential effects in duration require further exploration.PROSPERO, CRD42013003805.
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000144831 7001_ $$aSweegers, Maike G$$b1
000144831 7001_ $$aPeeters, Petra H M$$b2
000144831 7001_ $$aCourneya, Kerry S$$b3
000144831 7001_ $$aNewton, Robert U$$b4
000144831 7001_ $$aAaronson, Neil K$$b5
000144831 7001_ $$aJacobsen, Paul B$$b6
000144831 7001_ $$aGalvão, Daniel A$$b7
000144831 7001_ $$aChinapaw, Mai J$$b8
000144831 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b9$$udkfz
000144831 7001_ $$aIrwin, Melinda L$$b10
000144831 7001_ $$aStuiver, Martijn M$$b11
000144831 7001_ $$aHayes, Sandi$$b12
000144831 7001_ $$aGriffith, Kathleen A$$b13
000144831 7001_ $$aMesters, Ilse$$b14
000144831 7001_ $$aKnoop, Hans$$b15
000144831 7001_ $$aGoedendorp, Martine M$$b16
000144831 7001_ $$aMutrie, Nanette$$b17
000144831 7001_ $$aDaley, Amanda J$$b18
000144831 7001_ $$aMcConnachie, Alex$$b19
000144831 7001_ $$aBohus, Martin$$b20
000144831 7001_ $$aThorsen, Lene$$b21
000144831 7001_ $$aSchulz, Karl-Heinz$$b22
000144831 7001_ $$aShort, Camille E$$b23
000144831 7001_ $$aJames, Erica L$$b24
000144831 7001_ $$aPlotnikoff, Ronald C$$b25
000144831 7001_ $$0P:(DE-He78)2def8f8594c8f797f5ed4398258c6cac$$aSchmidt, Martina E$$b26$$udkfz
000144831 7001_ $$aUlrich, Cornelia M$$b27
000144831 7001_ $$avan Beurden, Marc$$b28
000144831 7001_ $$aOldenburg, Hester S$$b29
000144831 7001_ $$aSonke, Gabe S$$b30
000144831 7001_ $$avan Harten, Wim H$$b31
000144831 7001_ $$aSchmitz, Kathryn H$$b32
000144831 7001_ $$aWinters-Stone, Kerri M$$b33
000144831 7001_ $$aVelthuis, Miranda J$$b34
000144831 7001_ $$aTaaffe, Dennis R$$b35
000144831 7001_ $$avan Mechelen, Willem$$b36
000144831 7001_ $$aKersten, Marie José$$b37
000144831 7001_ $$aNollet, Frans$$b38
000144831 7001_ $$aWenzel, Jennifer$$b39
000144831 7001_ $$aWiskemann, Joachim$$b40
000144831 7001_ $$aVerdonck-de Leeuw, Irma M$$b41
000144831 7001_ $$aBrug, Johannes$$b42
000144831 7001_ $$aMay, Anne M$$b43
000144831 7001_ $$aBuffart, Laurien M$$b44
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