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@ARTICLE{vanVulpen:144831,
      author       = {J. K. van Vulpen and M. G. Sweegers and P. H. M. Peeters
                      and K. S. Courneya and R. U. Newton and N. K. Aaronson and
                      P. B. Jacobsen and D. A. Galvão and M. J. Chinapaw and K.
                      Steindorf$^*$ and M. L. Irwin and M. M. Stuiver and S. Hayes
                      and K. A. Griffith and I. Mesters and H. Knoop and M. M.
                      Goedendorp and N. Mutrie and A. J. Daley and A. McConnachie
                      and M. Bohus and L. Thorsen and K.-H. Schulz and C. E. Short
                      and E. L. James and R. C. Plotnikoff and M. E. Schmidt$^*$
                      and C. M. Ulrich and M. van Beurden and H. S. Oldenburg and
                      G. S. Sonke and W. H. van Harten and K. H. Schmitz and K. M.
                      Winters-Stone and M. J. Velthuis and D. R. Taaffe and W. van
                      Mechelen and M. J. Kersten and F. Nollet and J. Wenzel and
                      J. Wiskemann and I. M. Verdonck-de Leeuw and J. Brug and A.
                      M. May and L. M. Buffart},
      title        = {{M}oderators of {E}xercise {E}ffects on {C}ancer-related
                      {F}atigue: {A} {M}eta-analysis of {I}ndividual {P}atient
                      {D}ata.},
      journal      = {Medicine and science in sports and exercise},
      volume       = {52},
      number       = {2},
      issn         = {0195-9131},
      address      = {[s.l.]},
      publisher    = {Ovid},
      reportid     = {DKFZ-2019-02256},
      pages        = {303-314},
      year         = {2020},
      note         = {2020 Feb;52(2):303-314},
      abstract     = {Fatigue is a common and potentially disabling symptom in
                      patients with cancer. It can often be effectively reduced by
                      exercise. Yet, effects of exercise interventions might
                      differ across subgroups. We conducted a meta-analysis using
                      individual patient data of randomized controlled trials
                      (RCTs) to investigate moderators of exercise intervention
                      effects on cancer-related fatigue.We used individual patient
                      data from 31 exercise RCTs worldwide, representing 4,366
                      patients, of whom 3,846 had complete fatigue data. We
                      performed a one-step individual patient data meta-analysis,
                      using linear mixed-effect models to analyze the effects of
                      exercise interventions on fatigue (z-score) and to identify
                      demographic, clinical, intervention- and exercise-related
                      moderators. Models were adjusted for baseline fatigue and
                      included a random intercept on study level to account for
                      clustering of patients within studies. We identified
                      potential moderators by testing their interaction with group
                      allocation, using a likelihood ratio test.Exercise
                      interventions had statistically significant beneficial
                      effects on fatigue (β= -0.17 $[95\%$ confidence interval
                      (CI) -0.22;-0.12]). There was no evidence of moderation by
                      demographic or clinical characteristics. Supervised exercise
                      interventions had significantly larger effects on fatigue
                      than unsupervised exercise interventions (βdifference=
                      -0.18 $[95\%CI$ -0.28;-0.08]). Supervised interventions with
                      a duration ≤12 weeks showed larger effects on fatigue (β=
                      -0.29 $[95\%$ CI -0.39;-0.20]) than supervised interventions
                      with a longer duration. Conclusions - In this individual
                      patient data meta-analysis, we found statistically
                      significant beneficial effects of exercise interventions on
                      fatigue, irrespective of demographic and clinical
                      characteristics. These findings support a role for exercise,
                      preferably supervised exercise interventions, in clinical
                      practice. Reasons for differential effects in duration
                      require further exploration.PROSPERO, CRD42013003805.},
      cin          = {C110},
      ddc          = {796},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31524827},
      doi          = {10.1249/MSS.0000000000002154},
      url          = {https://inrepo02.dkfz.de/record/144831},
}