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| Home > Publications database > Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data. > print |
| 001 | 144831 | ||
| 005 | 20240229123020.0 | ||
| 024 | 7 | _ | |a 10.1249/MSS.0000000000002154 |2 doi |
| 024 | 7 | _ | |a pmid:31524827 |2 pmid |
| 024 | 7 | _ | |a 0025-7990 |2 ISSN |
| 024 | 7 | _ | |a 0195-9131 |2 ISSN |
| 024 | 7 | _ | |a 1530-0315 |2 ISSN |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 796 |
| 100 | 1 | _ | |a van Vulpen, Jonna K |b 0 |
| 245 | _ | _ | |a Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data. |
| 260 | _ | _ | |a [s.l.] |c 2020 |b Ovid |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1587465423_30799 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2020 Feb;52(2):303-314 |
| 520 | _ | _ | |a Fatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCTs) to investigate moderators of exercise intervention effects on cancer-related fatigue.We used individual patient data from 31 exercise RCTs worldwide, representing 4,366 patients, of whom 3,846 had complete fatigue data. We performed a one-step individual patient data meta-analysis, using linear mixed-effect models to analyze the effects of exercise interventions on fatigue (z-score) and to identify demographic, clinical, intervention- and exercise-related moderators. Models were adjusted for baseline fatigue and included a random intercept on study level to account for clustering of patients within studies. We identified potential moderators by testing their interaction with group allocation, using a likelihood ratio test.Exercise interventions had statistically significant beneficial effects on fatigue (β= -0.17 [95% confidence interval (CI) -0.22;-0.12]). There was no evidence of moderation by demographic or clinical characteristics. Supervised exercise interventions had significantly larger effects on fatigue than unsupervised exercise interventions (βdifference= -0.18 [95%CI -0.28;-0.08]). Supervised interventions with a duration ≤12 weeks showed larger effects on fatigue (β= -0.29 [95% CI -0.39;-0.20]) than supervised interventions with a longer duration. Conclusions - In this individual patient data meta-analysis, we found statistically significant beneficial effects of exercise interventions on fatigue, irrespective of demographic and clinical characteristics. These findings support a role for exercise, preferably supervised exercise interventions, in clinical practice. Reasons for differential effects in duration require further exploration.PROSPERO, CRD42013003805. |
| 536 | _ | _ | |a 313 - Cancer risk factors and prevention (POF3-313) |0 G:(DE-HGF)POF3-313 |c POF3-313 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Sweegers, Maike G |b 1 |
| 700 | 1 | _ | |a Peeters, Petra H M |b 2 |
| 700 | 1 | _ | |a Courneya, Kerry S |b 3 |
| 700 | 1 | _ | |a Newton, Robert U |b 4 |
| 700 | 1 | _ | |a Aaronson, Neil K |b 5 |
| 700 | 1 | _ | |a Jacobsen, Paul B |b 6 |
| 700 | 1 | _ | |a Galvão, Daniel A |b 7 |
| 700 | 1 | _ | |a Chinapaw, Mai J |b 8 |
| 700 | 1 | _ | |a Steindorf, Karen |0 P:(DE-He78)a0c2037d9054be26907a05ae520d5756 |b 9 |u dkfz |
| 700 | 1 | _ | |a Irwin, Melinda L |b 10 |
| 700 | 1 | _ | |a Stuiver, Martijn M |b 11 |
| 700 | 1 | _ | |a Hayes, Sandi |b 12 |
| 700 | 1 | _ | |a Griffith, Kathleen A |b 13 |
| 700 | 1 | _ | |a Mesters, Ilse |b 14 |
| 700 | 1 | _ | |a Knoop, Hans |b 15 |
| 700 | 1 | _ | |a Goedendorp, Martine M |b 16 |
| 700 | 1 | _ | |a Mutrie, Nanette |b 17 |
| 700 | 1 | _ | |a Daley, Amanda J |b 18 |
| 700 | 1 | _ | |a McConnachie, Alex |b 19 |
| 700 | 1 | _ | |a Bohus, Martin |b 20 |
| 700 | 1 | _ | |a Thorsen, Lene |b 21 |
| 700 | 1 | _ | |a Schulz, Karl-Heinz |b 22 |
| 700 | 1 | _ | |a Short, Camille E |b 23 |
| 700 | 1 | _ | |a James, Erica L |b 24 |
| 700 | 1 | _ | |a Plotnikoff, Ronald C |b 25 |
| 700 | 1 | _ | |a Schmidt, Martina E |0 P:(DE-He78)2def8f8594c8f797f5ed4398258c6cac |b 26 |u dkfz |
| 700 | 1 | _ | |a Ulrich, Cornelia M |b 27 |
| 700 | 1 | _ | |a van Beurden, Marc |b 28 |
| 700 | 1 | _ | |a Oldenburg, Hester S |b 29 |
| 700 | 1 | _ | |a Sonke, Gabe S |b 30 |
| 700 | 1 | _ | |a van Harten, Wim H |b 31 |
| 700 | 1 | _ | |a Schmitz, Kathryn H |b 32 |
| 700 | 1 | _ | |a Winters-Stone, Kerri M |b 33 |
| 700 | 1 | _ | |a Velthuis, Miranda J |b 34 |
| 700 | 1 | _ | |a Taaffe, Dennis R |b 35 |
| 700 | 1 | _ | |a van Mechelen, Willem |b 36 |
| 700 | 1 | _ | |a Kersten, Marie José |b 37 |
| 700 | 1 | _ | |a Nollet, Frans |b 38 |
| 700 | 1 | _ | |a Wenzel, Jennifer |b 39 |
| 700 | 1 | _ | |a Wiskemann, Joachim |b 40 |
| 700 | 1 | _ | |a Verdonck-de Leeuw, Irma M |b 41 |
| 700 | 1 | _ | |a Brug, Johannes |b 42 |
| 700 | 1 | _ | |a May, Anne M |b 43 |
| 700 | 1 | _ | |a Buffart, Laurien M |b 44 |
| 773 | _ | _ | |a 10.1249/MSS.0000000000002154 |g p. 1 - |0 PERI:(DE-600)2031167-9 |n 2 |p 303-314 |t Medicine and science in sports and exercise |v 52 |y 2020 |x 0195-9131 |
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