%0 Journal Article
%A Forster, Tobias
%A Akbaba, Sati
%A Schmitt, Daniela
%A Krug, David
%A El Shafie, Rami
%A Oelmann-Avendano, Jan
%A Lindel, Katja
%A König, Laila
%A Arians, Nathalie
%A Bernhardt, Denise
%A Marmé, Frederik
%A Schneeweiss, Andreas
%A Heil, Jörg
%A Sohn, Christof
%A Debus, Jürgen
%A Hörner-Rieber, Juliane
%T Second breast conserving therapy after ipsilateral breast tumor recurrence - a 10-year experience of re-irradiation.
%J Journal of contemporary brachytherapy
%V 11
%N 4
%@ 1689-832X
%C Poznań
%I Termedia
%M DKFZ-2019-02258
%P 312 - 319
%D 2019
%X The aim of this study is to evaluate the efficacy and toxicity of post-operative partial breast re-irradiation with multi-catheter brachytherapy after second breast conserving therapy (BCT) in patients with small, low-risk ipsilateral breast tumor recurrence (IBTR).Between 2008 and 2018, 19 consecutive patients with low-risk IBTR (max. rpT1 cN0 cM0, Her2 negative, preferably positive hormone receptor status) who refused mastectomy were treated with salvage lumpectomy, followed by post-operative partial breast re-irradiation with multi-catheter brachytherapy. Eight patients were irradiated using PDR brachytherapy (49.8-50.4 Gy in pulses of 0.5-0.7 Gy) and 11 patients using HDR brachytherapy (34.2 Gy in fractions of 3.8 Gy or 32 Gy in fractions of 4 Gy). All patients had undergone prior BCT for their primary tumor, followed by adjuvant whole breast radiotherapy. Local control (LC), locoregional control (LRC), overall survival (OS), disease-free survival (DFS) as well as toxicity were evaluated in the present study.After a median follow-up of 65 months following IBTR (18-120 months), only one second IBTR in 19 patients was diagnosed 77 months after re-irradiation, resulting in a LC rate of 100
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31523231
%2 pmc:PMC6737570
%R 10.5114/jcb.2019.87001
%U https://inrepo02.dkfz.de/record/144833