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| 001 | 144833 | ||
| 005 | 20240229112639.0 | ||
| 024 | 7 | _ | |a 10.5114/jcb.2019.87001 |2 doi |
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| 100 | 1 | _ | |a Forster, Tobias |b 0 |
| 245 | _ | _ | |a Second breast conserving therapy after ipsilateral breast tumor recurrence - a 10-year experience of re-irradiation. |
| 260 | _ | _ | |a Poznań |c 2019 |b Termedia |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a The aim of this study is to evaluate the efficacy and toxicity of post-operative partial breast re-irradiation with multi-catheter brachytherapy after second breast conserving therapy (BCT) in patients with small, low-risk ipsilateral breast tumor recurrence (IBTR).Between 2008 and 2018, 19 consecutive patients with low-risk IBTR (max. rpT1 cN0 cM0, Her2 negative, preferably positive hormone receptor status) who refused mastectomy were treated with salvage lumpectomy, followed by post-operative partial breast re-irradiation with multi-catheter brachytherapy. Eight patients were irradiated using PDR brachytherapy (49.8-50.4 Gy in pulses of 0.5-0.7 Gy) and 11 patients using HDR brachytherapy (34.2 Gy in fractions of 3.8 Gy or 32 Gy in fractions of 4 Gy). All patients had undergone prior BCT for their primary tumor, followed by adjuvant whole breast radiotherapy. Local control (LC), locoregional control (LRC), overall survival (OS), disease-free survival (DFS) as well as toxicity were evaluated in the present study.After a median follow-up of 65 months following IBTR (18-120 months), only one second IBTR in 19 patients was diagnosed 77 months after re-irradiation, resulting in a LC rate of 100% at 5 years. DFS and OS rates were both 100% at 5 years following re-irradiation. Except for the above mentioned second IBTR, no regional or distant relapse was recorded. Regarding toxicity, 63% of patients developed adverse events (CTCAE grade ≤ 2), with fibrosis detected in 37% (7/19) of patients, necrosis in 11% (2/19), hyperpigmentation in 47% (9/19), and telangiectasia in 11% (2/19), respectively. No patient showed a high-grade (CTCAE grade ≥ 3) adverse event.In case of small, low-risk IBTR, adjuvant re-irradiation using multi-catheter brachytherapy is a feasible, safe, and effective treatment method after repeated lumpectomy, and an alternative to mastectomy. |
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| 700 | 1 | _ | |a Akbaba, Sati |b 1 |
| 700 | 1 | _ | |a Schmitt, Daniela |b 2 |
| 700 | 1 | _ | |a Krug, David |b 3 |
| 700 | 1 | _ | |a El Shafie, Rami |b 4 |
| 700 | 1 | _ | |a Oelmann-Avendano, Jan |b 5 |
| 700 | 1 | _ | |a Lindel, Katja |b 6 |
| 700 | 1 | _ | |a König, Laila |b 7 |
| 700 | 1 | _ | |a Arians, Nathalie |b 8 |
| 700 | 1 | _ | |a Bernhardt, Denise |b 9 |
| 700 | 1 | _ | |a Marmé, Frederik |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Schneeweiss, Andreas |b 11 |
| 700 | 1 | _ | |a Heil, Jörg |b 12 |
| 700 | 1 | _ | |a Sohn, Christof |b 13 |
| 700 | 1 | _ | |a Debus, Jürgen |0 P:(DE-He78)8714da4e45acfa36ce87c291443a9218 |b 14 |
| 700 | 1 | _ | |a Hörner-Rieber, Juliane |0 P:(DE-He78)c59ff25b48c192ed3fd4ad3a4bc9b9c0 |b 15 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.5114/jcb.2019.87001 |g Vol. 11, no. 4, p. 312 - 319 |0 PERI:(DE-600)2627721-9 |n 4 |p 312 - 319 |t Journal of contemporary brachytherapy |v 11 |y 2019 |x 1689-832X |
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