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000144849 1001_ $$0P:(DE-HGF)0$$aVenkataramani, Varun$$b0$$eFirst author
000144849 245__ $$aGlutamatergic synaptic input to glioma cells drives brain tumour progression.
000144849 260__ $$aLondon [u.a.]$$bNature Publ. Group52462$$c2019
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000144849 520__ $$aA network of communicating tumour cells that is connected by tumour microtubes mediates the progression of incurable gliomas. Moreover, neuronal activity can foster malignant behaviour of glioma cells by non-synaptic paracrine and autocrine mechanisms. Here we report a direct communication channel between neurons and glioma cells in different disease models and human tumours: functional bona fide chemical synapses between presynaptic neurons and postsynaptic glioma cells. These neurogliomal synapses show a typical synaptic ultrastructure, are located on tumour microtubes, and produce postsynaptic currents that are mediated by glutamate receptors of the AMPA subtype. Neuronal activity including epileptic conditions generates synchronised calcium transients in tumour-microtube-connected glioma networks. Glioma-cell-specific genetic perturbation of AMPA receptors reduces calcium-related invasiveness of tumour-microtube-positive tumour cells and glioma growth. Invasion and growth are also reduced by anaesthesia and the AMPA receptor antagonist perampanel, respectively. These findings reveal a biologically relevant direct synaptic communication between neurons and glioma cells with potential clinical implications.
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000144849 7001_ $$0P:(DE-HGF)0$$aTanev, Dimitar Ivanov$$b1
000144849 7001_ $$aStrahle, Christopher$$b2
000144849 7001_ $$0P:(DE-HGF)0$$aStudier-Fischer, Alexander$$b3
000144849 7001_ $$0P:(DE-HGF)0$$aFankhauser, Laura$$b4
000144849 7001_ $$0P:(DE-He78)5c2c9cbe6ce72553684d82d94aebdadd$$aKessler, Tobias$$b5
000144849 7001_ $$aKörber, Christoph$$b6
000144849 7001_ $$aKardorff, Markus$$b7
000144849 7001_ $$0P:(DE-HGF)0$$aRatliff, Miriam$$b8
000144849 7001_ $$0P:(DE-He78)07de1c0592124175413da2fb91f61b5a$$aXie, Ruifan$$b9
000144849 7001_ $$aHorstmann, Heinz$$b10
000144849 7001_ $$0P:(DE-He78)10432eed0573b1a7ff98360250c957ae$$aMesser, Mirko$$b11
000144849 7001_ $$aPaik, Sang Peter$$b12
000144849 7001_ $$aKnabbe, Johannes$$b13
000144849 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b14
000144849 7001_ $$aKurz, Felix T$$b15
000144849 7001_ $$0P:(DE-He78)7063389c6358eac8cf4cfed06bfde7b1$$aAcikgöz, Azer Aylin$$b16
000144849 7001_ $$aHerrmannsdörfer, Frank$$b17
000144849 7001_ $$aAgarwal, Amit$$b18
000144849 7001_ $$aBergles, Dwight E$$b19
000144849 7001_ $$aChalmers, Anthony$$b20
000144849 7001_ $$aMiletic, Hrvoje$$b21
000144849 7001_ $$aTurcan, Sevin$$b22
000144849 7001_ $$aMawrin, Christian$$b23
000144849 7001_ $$aHänggi, Daniel$$b24
000144849 7001_ $$0P:(DE-He78)76aeb2431f7458c9261e69c5420390c6$$aLiu, Hai-Kun$$b25
000144849 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b26
000144849 7001_ $$0P:(DE-He78)6c294453ee36ad59deddc5494fa6aa4b$$aWinkler, Frank$$b27$$eLast author
000144849 7001_ $$aKuner, Thomas$$b28
000144849 773__ $$0PERI:(DE-600)1413423-8$$a10.1038/s41586-019-1564-x$$n7775$$p532-538$$tNature <London>$$v573$$x1476-4687$$y2019
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