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000144851 0247_ $$2doi$$a10.1080/09553002.2019.1665209
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000144851 0247_ $$2ISSN$$a0020-7616
000144851 0247_ $$2ISSN$$a0955-3002
000144851 0247_ $$2ISSN$$a1362-3095
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000144851 037__ $$aDKFZ-2019-02275
000144851 041__ $$aeng
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000144851 1001_ $$0P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215$$aSeibold, Petra$$b0$$eFirst author$$udkfz
000144851 245__ $$aClinical and epidemiological observations on individual radiation sensitivity and susceptibility.
000144851 260__ $$aAbingdon$$bInforma Healthcare58475$$c2020
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000144851 500__ $$a2020 Mar;96(3):324-339#EA:C020#
000144851 520__ $$aPurpose: To summarize existing knowledge and to understand individual response to radiation exposure, the MELODI Association together with CONCERT European Joint Programme has organized a workshop in March 2018 on radiation sensitivity and susceptibility. Methods: The workshop reviewed the current evidence on this matter, to inform the MELODI Strategic Research Agenda (SRA), to determine social and scientific needs and to come up with recommendations for suitable and feasible future research initiatives to be taken for the benefit of an improved medical diagnosis and treatment as well as for radiation protection. Results: The present paper gives an overview of the current evidence in this field, including potential effect modifiers such as age, gender, genetic profile, and health status of the exposed population, based on clinical and epidemiological observations. Conclusion: The authors conclude with the following recommendations for the way forward in radiation research: (a) there is need for large (prospective) cohort studies; (b) build upon existing radiation research cohorts; (c) use data from well-defined cohorts with good exposure assessment and biological material already collected; (d) focus on study quality with standardized data collection and reporting; (e) improve statistical analysis; (f) cooperation between radiobiology and epidemiology; and (g) take consequences of radiosensitivity and radiosusceptibility into account.
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000144851 7001_ $$aAuvinen, Anssi$$b1
000144851 7001_ $$aAverbeck, Dietrich$$b2
000144851 7001_ $$aBourguignon, Michel$$b3
000144851 7001_ $$aHartikainen, Jaana M$$b4
000144851 7001_ $$aHoeschen, Christoph$$b5
000144851 7001_ $$aLaurent, Olivier$$b6
000144851 7001_ $$aNoël, Georges$$b7
000144851 7001_ $$aSabatier, Laure$$b8
000144851 7001_ $$aSalomaa, Sisko$$b9
000144851 7001_ $$aBlettner, Maria$$b10
000144851 773__ $$0PERI:(DE-600)3065-x$$a10.1080/09553002.2019.1665209$$gp. 1 - 16$$n3$$p324-339$$tInternational journal of radiation biology$$v96$$x1362-3095$$y2020
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