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@ARTICLE{Seibold:144851,
      author       = {P. Seibold$^*$ and A. Auvinen and D. Averbeck and M.
                      Bourguignon and J. M. Hartikainen and C. Hoeschen and O.
                      Laurent and G. Noël and L. Sabatier and S. Salomaa and M.
                      Blettner},
      title        = {{C}linical and epidemiological observations on individual
                      radiation sensitivity and susceptibility.},
      journal      = {International journal of radiation biology},
      volume       = {96},
      number       = {3},
      issn         = {1362-3095},
      address      = {Abingdon},
      publisher    = {Informa Healthcare58475},
      reportid     = {DKFZ-2019-02275},
      pages        = {324-339},
      year         = {2020},
      note         = {2020 Mar;96(3):324-339#EA:C020#},
      abstract     = {Purpose: To summarize existing knowledge and to understand
                      individual response to radiation exposure, the MELODI
                      Association together with CONCERT European Joint Programme
                      has organized a workshop in March 2018 on radiation
                      sensitivity and susceptibility. Methods: The workshop
                      reviewed the current evidence on this matter, to inform the
                      MELODI Strategic Research Agenda (SRA), to determine social
                      and scientific needs and to come up with recommendations for
                      suitable and feasible future research initiatives to be
                      taken for the benefit of an improved medical diagnosis and
                      treatment as well as for radiation protection. Results: The
                      present paper gives an overview of the current evidence in
                      this field, including potential effect modifiers such as
                      age, gender, genetic profile, and health status of the
                      exposed population, based on clinical and epidemiological
                      observations. Conclusion: The authors conclude with the
                      following recommendations for the way forward in radiation
                      research: (a) there is need for large (prospective) cohort
                      studies; (b) build upon existing radiation research cohorts;
                      (c) use data from well-defined cohorts with good exposure
                      assessment and biological material already collected; (d)
                      focus on study quality with standardized data collection and
                      reporting; (e) improve statistical analysis; (f) cooperation
                      between radiobiology and epidemiology; and (g) take
                      consequences of radiosensitivity and radiosusceptibility
                      into account.},
      subtyp        = {Review Article},
      cin          = {C020},
      ddc          = {570},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31539290},
      doi          = {10.1080/09553002.2019.1665209},
      url          = {https://inrepo02.dkfz.de/record/144851},
}