%0 Journal Article
%A Bösch, Florian
%A Todorova, Rumyana
%A Link, Helena
%A Westphalen, C Benedikt
%A Boeck, Stefan
%A Heinemann, Volker
%A Werner, Jens
%A Kirchner, Thomas
%A Angele, Martin K
%A Neumann, Jens
%T Molecular subtyping of gastric cancer with respect to the growth pattern of lymph-node metastases.
%J Journal of cancer research and clinical oncology
%V 145
%N 11
%@ 0171-5216
%C Berlin
%I Springer42162
%M DKFZ-2019-02278
%P 2689-2697
%D 2019
%X Gastric cancer is the third leading cause of cancer-related death. Recently, innovative diagnostic and prognostic molecular subtypes have been proposed. We revealed that extranodal extension (ENE) of lymph-node metastases independently influences survival. Therefore, the aim of the present study was to evaluate novel molecular subtyping with regard to the growth pattern of lymph-node metastases.A total of 189 gastric carcinomas with lymph-node metastases were analyzed. The expression of p53, SOX2, SOX9, and the mismatch-repair gene products MLH1, PMS2, MSH2, and MSH6 were analyzed by immunohistochemistry. To determine the correlation with EBV infection, in situ hybridization for EBV-encoded small RNA (EBER) was applied.ENE was present in 36
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31541339
%R 10.1007/s00432-019-03029-4
%U https://inrepo02.dkfz.de/record/144854