TY  - JOUR
AU  - Bösch, Florian
AU  - Todorova, Rumyana
AU  - Link, Helena
AU  - Westphalen, C Benedikt
AU  - Boeck, Stefan
AU  - Heinemann, Volker
AU  - Werner, Jens
AU  - Kirchner, Thomas
AU  - Angele, Martin K
AU  - Neumann, Jens
TI  - Molecular subtyping of gastric cancer with respect to the growth pattern of lymph-node metastases.
JO  - Journal of cancer research and clinical oncology
VL  - 145
IS  - 11
SN  - 0171-5216
CY  - Berlin
PB  - Springer42162
M1  - DKFZ-2019-02278
SP  - 2689-2697
PY  - 2019
AB  - Gastric cancer is the third leading cause of cancer-related death. Recently, innovative diagnostic and prognostic molecular subtypes have been proposed. We revealed that extranodal extension (ENE) of lymph-node metastases independently influences survival. Therefore, the aim of the present study was to evaluate novel molecular subtyping with regard to the growth pattern of lymph-node metastases.A total of 189 gastric carcinomas with lymph-node metastases were analyzed. The expression of p53, SOX2, SOX9, and the mismatch-repair gene products MLH1, PMS2, MSH2, and MSH6 were analyzed by immunohistochemistry. To determine the correlation with EBV infection, in situ hybridization for EBV-encoded small RNA (EBER) was applied.ENE was present in 36
LB  - PUB:(DE-HGF)16
C6  - pmid:31541339
DO  - DOI:10.1007/s00432-019-03029-4
UR  - https://inrepo02.dkfz.de/record/144854
ER  -