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@ARTICLE{Bsch:144854,
      author       = {F. Bösch and R. Todorova and H. Link and C. B. Westphalen
                      and S. Boeck and V. Heinemann and J. Werner and T.
                      Kirchner$^*$ and M. K. Angele and J. Neumann},
      title        = {{M}olecular subtyping of gastric cancer with respect to the
                      growth pattern of lymph-node metastases.},
      journal      = {Journal of cancer research and clinical oncology},
      volume       = {145},
      number       = {11},
      issn         = {0171-5216},
      address      = {Berlin},
      publisher    = {Springer42162},
      reportid     = {DKFZ-2019-02278},
      pages        = {2689-2697},
      year         = {2019},
      abstract     = {Gastric cancer is the third leading cause of cancer-related
                      death. Recently, innovative diagnostic and prognostic
                      molecular subtypes have been proposed. We revealed that
                      extranodal extension (ENE) of lymph-node metastases
                      independently influences survival. Therefore, the aim of the
                      present study was to evaluate novel molecular subtyping with
                      regard to the growth pattern of lymph-node metastases.A
                      total of 189 gastric carcinomas with lymph-node metastases
                      were analyzed. The expression of p53, SOX2, SOX9, and the
                      mismatch-repair gene products MLH1, PMS2, MSH2, and MSH6
                      were analyzed by immunohistochemistry. To determine the
                      correlation with EBV infection, in situ hybridization for
                      EBV-encoded small RNA (EBER) was applied.ENE was present in
                      $36\%$ of patients. EBV-positive carcinoma was evident in
                      $5.8\%,$ and p53 aberrant (chromosomal instable) tumors in
                      $22.2\%,$ a gastric cancer with deficient mismatch-repair
                      status in $9\%,$ and MSS/p53neg/EBVneg tumors were seen in
                      $63\%$ of patients. There was no significant correlation
                      between the presence or absence of ENE and the molecular
                      subtypes. However, a significant association between
                      molecular subgroups and the Lauren classification, the
                      oncogene SOX2, and tumor grading was detected.The present
                      findings suggest that alterations in gastric cancer leading
                      to ENE are not associated with alterations underpinning the
                      molecular subgroups. Nonetheless, molecular subtyping on the
                      basis of IHC and ISH is feasible and might become clinical
                      routine. Thus, further studies are needed to clarify the
                      mechanisms of extranodal extension in gastric cancer.},
      cin          = {E131 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)E131-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31541339},
      doi          = {10.1007/s00432-019-03029-4},
      url          = {https://inrepo02.dkfz.de/record/144854},
}