TY  - JOUR
AU  - Holleczek, Bernd
AU  - Schöttker, Ben
AU  - Brenner, Hermann
TI  - Helicobacter pylori infection, chronic atrophic gastritis and risk of stomach and esophagus cancer: Results from the prospective population-based ESTHER cohort study.
JO  - International journal of cancer
VL  - 146
IS  - 10
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2019-02299
SP  - 2773-2783
PY  - 2020
N1  - 2020 May 15;146(10):2773-2783#EA:C070#LA:C070#
AB  - Helicobacter pylori (H. pylori) infection is considered as principal cause of gastric cancer. It is further associated with a reduced risk of esophageal adenocarcinomas. In a large prospective population-based cohort study including 9,949 subjects with average observation time of 13.8 years, we assessed the risk of invasive gastric and esophageal cancer according to H. pylori infection and presence of chronic atrophic gastritis (CAG). Incidence rates and hazard ratios (HR) derived by Cox proportional hazards models and adjusted for relevant confounders were derived by seroprevalence of H. pylori and cytotoxin-associated gene A (CagA) antibodies and presence of CAG based on serological markers at baseline, respectively. During follow-up, 30 cases of noncardia gastric cancer and 33 cases of esophageal cancer were observed. Infection by H. pylori without and with expression of CagA was associated with a 5.2-fold (95
LB  - PUB:(DE-HGF)16
C6  - pmid:31376284
DO  - DOI:10.1002/ijc.32610
UR  - https://inrepo02.dkfz.de/record/144875
ER  -