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000144880 1001_ $$00000-0002-8178-2125$$aVrieling, Alina$$b0
000144880 245__ $$aOne-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition.
000144880 260__ $$aBognor Regis$$bWiley-Liss$$c2019
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000144880 520__ $$aPublished associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81, p-interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81-1.95; p-heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.
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000144880 7001_ $$aBueno-De-Mesquita, H Bas$$b1
000144880 7001_ $$aRos, Martine M$$b2
000144880 7001_ $$aKampman, Ellen$$b3
000144880 7001_ $$aAben, Katja K$$b4
000144880 7001_ $$aBüchner, Frederike L$$b5
000144880 7001_ $$aJansen, Eugène H$$b6
000144880 7001_ $$00000-0003-3071-1658$$aRoswall, Nina$$b7
000144880 7001_ $$aTjønneland, Anne$$b8
000144880 7001_ $$00000-0002-5956-5693$$aBoutron-Ruault, Marie-Christine$$b9
000144880 7001_ $$aCadeau, Claire$$b10
000144880 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b11$$udkfz
000144880 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b12$$udkfz
000144880 7001_ $$aWeikert, Steffen$$b13
000144880 7001_ $$aBoeing, Heiner$$b14
000144880 7001_ $$aTrichopoulou, Antonia$$b15
000144880 7001_ $$aLagiou, Pagona$$b16
000144880 7001_ $$aTrichopoulos, Dimitrios$$b17
000144880 7001_ $$aSieri, Sabina$$b18
000144880 7001_ $$00000-0002-5558-2437$$aPalli, Domenico$$b19
000144880 7001_ $$aPanico, Salvatore$$b20
000144880 7001_ $$aPeeters, Petra H$$b21
000144880 7001_ $$aWeiderpass, Elisabete$$b22
000144880 7001_ $$aSkeie, Guri$$b23
000144880 7001_ $$aJakszyn, Paula$$b24
000144880 7001_ $$aChirlaque, María-Dolores$$b25
000144880 7001_ $$aArdanaz, Eva$$b26
000144880 7001_ $$aSánchez, María-José$$b27
000144880 7001_ $$aEhrnström, Roy$$b28
000144880 7001_ $$aMalm, Johan$$b29
000144880 7001_ $$aLjungberg, Börje$$b30
000144880 7001_ $$aKhaw, Kay-Tee$$b31
000144880 7001_ $$aWareham, Nick J$$b32
000144880 7001_ $$aBrennan, Paul$$b33
000144880 7001_ $$aJohansson, Mattias$$b34
000144880 7001_ $$aRiboli, Elio$$b35
000144880 7001_ $$aKiemeney, Lambertus A$$b36
000144880 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.32165$$gVol. 145, no. 9, p. 2349 - 2359$$n9$$p2349 - 2359$$tInternational journal of cancer$$v145$$x1097-0215$$y2019
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