000147186 001__ 147186 000147186 005__ 20240229123021.0 000147186 0247_ $$2doi$$a10.1093/ije/dyz193 000147186 0247_ $$2pmid$$apmid:31605532 000147186 0247_ $$2ISSN$$a0300-5771 000147186 0247_ $$2ISSN$$a1464-3685 000147186 0247_ $$2altmetric$$aaltmetric:68296786 000147186 037__ $$aDKFZ-2019-02322 000147186 041__ $$aeng 000147186 082__ $$a610 000147186 1001_ $$0P:(DE-HGF)0$$aKapoor, Pooja Middha$$b0$$eFirst author 000147186 245__ $$aAssessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium. 000147186 260__ $$aOxford$$bOxford Univ. Press$$c2020 000147186 3367_ $$2DRIVER$$aarticle 000147186 3367_ $$2DataCite$$aOutput Types/Journal article 000147186 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1636632163_5417 000147186 3367_ $$2BibTeX$$aARTICLE 000147186 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000147186 3367_ $$00$$2EndNote$$aJournal Article 000147186 500__ $$a2020 Feb 1;49(1):216-232#EA:C020# 000147186 520__ $$aPrevious gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Using the largest available dataset to date, we performed a comprehensive assessment of potential effect modification of 205 common susceptibility variants by 13 established breast cancer risk factors, including replication of previously reported interactions.Analyses were performed using 28 176 cases and 32 209 controls genotyped with iCOGS array and 44 109 cases and 48 145 controls genotyped using OncoArray from the Breast Cancer Association Consortium (BCAC). Gene-environment interactions were assessed using unconditional logistic regression and likelihood ratio tests for breast cancer risk overall and by estrogen-receptor (ER) status. Bayesian false discovery probability was used to assess the noteworthiness of the meta-analysed array-specific interactions.Noteworthy evidence of interaction at ≤1% prior probability was observed for three single nucleotide polymorphism (SNP)-risk factor pairs. SNP rs4442975 was associated with a greater reduction of risk of ER-positive breast cancer [odds ratio (OR)int = 0.85 (0.78-0.93), Pint = 2.8 x 10-4] and overall breast cancer [ORint = 0.85 (0.78-0.92), Pint = 7.4 x 10-5) in current users of estrogen-progesterone therapy compared with non-users. This finding was supported by replication using OncoArray data of the previously reported interaction between rs13387042 (r2 = 0.93 with rs4442975) and current estrogen-progesterone therapy for overall disease (Pint = 0.004). The two other interactions suggested stronger associations between SNP rs6596100 and ER-negative breast cancer with increasing parity and younger age at first birth.Overall, our study does not suggest strong effect modification of common breast cancer susceptibility variants by established risk factors. 000147186 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0 000147186 588__ $$aDataset connected to CrossRef, PubMed, 000147186 7001_ $$aLindström, Sara$$b1 000147186 7001_ $$0P:(DE-He78)6b04712f3afe72044d496a25505cb1ea$$aBehrens, Sabine$$b2 000147186 7001_ $$aWang, Xiaoliang$$b3 000147186 7001_ $$aMichailidou, Kyriaki$$b4 000147186 7001_ $$aBolla, Manjeet K$$b5 000147186 7001_ $$aWang, Qin$$b6 000147186 7001_ $$aDennis, Joe$$b7 000147186 7001_ $$aDunning, Alison M$$b8 000147186 7001_ $$aPharoah, Paul D P$$b9 000147186 7001_ $$aSchmidt, Marjanka K$$b10 000147186 7001_ $$aKraft, Peter$$b11 000147186 7001_ $$aGarcía-Closas, Montserrat$$b12 000147186 7001_ $$aEaston, Douglas F$$b13 000147186 7001_ $$aMilne, Roger L$$b14 000147186 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b15 000147186 7001_ $$aConsortium, Breast Cancer Association$$b16$$eCollaboration Author 000147186 7001_ $$aAhearn, Thomas$$b17 000147186 7001_ $$aAndrulis, Irene L$$b18 000147186 7001_ $$aAnton-Culver, Hoda$$b19 000147186 7001_ $$0P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0$$aArndt, Volker$$b20$$udkfz 000147186 7001_ $$aAronson, Kristan J$$b21 000147186 7001_ $$aAuer, Paul L$$b22 000147186 7001_ $$aAugustinsson, Annelie$$b23 000147186 7001_ $$aFreeman, Laura E Beane$$b24 000147186 7001_ $$aBeckmann, Matthias W$$b25 000147186 7001_ $$aBenitez, Javier$$b26 000147186 7001_ $$aBernstein, Leslie$$b27 000147186 7001_ $$aBerrandou, Takiy$$b28 000147186 7001_ $$aBojesen, Stig E$$b29 000147186 7001_ $$aBrauch, Hiltrud$$b30 000147186 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b31 000147186 7001_ $$aBrock, Ian W$$b32 000147186 7001_ $$aBroeks, Annegien$$b33 000147186 7001_ $$aBrooks-Wilson, Angela$$b34 000147186 7001_ $$0P:(DE-He78)7ca7eafba864e5c3ebb7598149380452$$aButterbach, Katja$$b35 000147186 7001_ $$aCai, Qiuyin$$b36 000147186 7001_ $$aCampa, Daniele$$b37 000147186 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b38 000147186 7001_ $$aCarter, Brian D$$b39 000147186 7001_ $$aCastelao, Jose E$$b40 000147186 7001_ $$aChanock, Stephen J$$b41 000147186 7001_ $$aChenevix-Trench, Georgia$$b42 000147186 7001_ $$aCheng, Ting-Yuan David$$b43 000147186 7001_ $$aClarke, Christine L$$b44 000147186 7001_ $$aCordina-Duverger, Emilie$$b45 000147186 7001_ $$aCouch, Fergus J$$b46 000147186 7001_ $$aCox, Angela$$b47 000147186 7001_ $$aCross, Simon S$$b48 000147186 7001_ $$aCzene, Kamila$$b49 000147186 7001_ $$aDai, James Y$$b50 000147186 7001_ $$aDite, Gillian S$$b51 000147186 7001_ $$aEarp, H Shelton$$b52 000147186 7001_ $$aEliassen, A Heather$$b53 000147186 7001_ $$aEriksson, Mikael$$b54 000147186 7001_ $$aEvans, D Gareth$$b55 000147186 7001_ $$aFasching, Peter A$$b56 000147186 7001_ $$aFigueroa, Jonine$$b57 000147186 7001_ $$aFlyger, Henrik$$b58 000147186 7001_ $$aFritschi, Lin$$b59 000147186 7001_ $$aGabrielson, Marike$$b60 000147186 7001_ $$aGago-Dominguez, Manuela$$b61 000147186 7001_ $$aGapstur, Susan M$$b62 000147186 7001_ $$aGaudet, Mia M$$b63 000147186 7001_ $$aGiles, Graham G$$b64 000147186 7001_ $$aGonzález-Neira, Anna$$b65 000147186 7001_ $$aGrundy, Anne$$b66 000147186 7001_ $$aGuénel, Pascal$$b67 000147186 7001_ $$aHaeberle, Lothar$$b68 000147186 7001_ $$aHaiman, Christopher A$$b69 000147186 7001_ $$aHåkansson, Niclas$$b70 000147186 7001_ $$aHall, Per$$b71 000147186 7001_ $$0P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b$$aHamann, Ute$$b72 000147186 7001_ $$aHankinson, Susan E$$b73 000147186 7001_ $$aHarkness, Elaine F$$b74 000147186 7001_ $$aHarstad, Tricia$$b75 000147186 7001_ $$aHe, Wei$$b76 000147186 7001_ $$aHeyworth, Jane$$b77 000147186 7001_ $$aHoover, Robert N$$b78 000147186 7001_ $$aHopper, John L$$b79 000147186 7001_ $$aHumphreys, Keith$$b80 000147186 7001_ $$aHunter, David J$$b81 000147186 7001_ $$aMarrón, Pablo Isidro$$b82 000147186 7001_ $$aJohn, Esther M$$b83 000147186 7001_ $$aJones, Michael E$$b84 000147186 7001_ $$0P:(DE-He78)bce1fdec5ce564e2666156d96aeabec9$$aJung, Audrey$$b85$$udkfz 000147186 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b86 000147186 7001_ $$aKeeman, Renske$$b87 000147186 7001_ $$aKitahara, Cari M$$b88 000147186 7001_ $$aKo, Yon-Dschun$$b89 000147186 7001_ $$aKoutros, Stella$$b90 000147186 7001_ $$aKrüger, Ute$$b91 000147186 7001_ $$aLambrechts, Diether$$b92 000147186 7001_ $$aMarchand, Loic Le$$b93 000147186 7001_ $$aLee, Eunjung$$b94 000147186 7001_ $$aLejbkowicz, Flavio$$b95 000147186 7001_ $$aLinet, Martha$$b96 000147186 7001_ $$aLissowska, Jolanta$$b97 000147186 7001_ $$aLlaneza, Ana$$b98 000147186 7001_ $$aLo, Wing-Yee$$b99 000147186 7001_ $$aMakalic, Enes$$b100 000147186 7001_ $$aMartinez, Maria Elena$$b101 000147186 7001_ $$aMaurer, Tabea$$b102 000147186 7001_ $$aMuñoz-Garzon, Victor M$$b103 000147186 7001_ $$aNeuhausen, Susan L$$b104 000147186 7001_ $$aNeven, Patrick$$b105 000147186 7001_ $$aNewman, William G$$b106 000147186 7001_ $$aNielsen, Sune F$$b107 000147186 7001_ $$aNordestgaard, Børge G$$b108 000147186 7001_ $$aNorman, Aaron$$b109 000147186 7001_ $$aO'Brien, Katie M$$b110 000147186 7001_ $$aOlshan, Andrew F$$b111 000147186 7001_ $$aOlson, Janet E$$b112 000147186 7001_ $$aOlsson, Håkan$$b113 000147186 7001_ $$aOrr, Nick$$b114 000147186 7001_ $$aPerou, Charles M$$b115 000147186 7001_ $$aPinchev, Mila$$b116 000147186 7001_ $$aPrentice, Ross$$b117 000147186 7001_ $$aRennert, Gad$$b118 000147186 7001_ $$aRennert, Hedy S$$b119 000147186 7001_ $$aRuddy, Kathryn J$$b120 000147186 7001_ $$aSandler, Dale P$$b121 000147186 7001_ $$aSchneider, Michael O$$b122 000147186 7001_ $$aSchoemaker, Minouk J$$b123 000147186 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b124$$udkfz 000147186 7001_ $$aScott, Rodney J$$b125 000147186 7001_ $$aScott, Christopher$$b126 000147186 7001_ $$aSherman, Mark E$$b127 000147186 7001_ $$aShrubsole, Martha J$$b128 000147186 7001_ $$aShu, Xiao-Ou$$b129 000147186 7001_ $$aSouthey, Melissa C$$b130 000147186 7001_ $$aSpinelli, John J$$b131 000147186 7001_ $$aStone, Jennifer$$b132 000147186 7001_ $$aSwerdlow, Anthony J$$b133 000147186 7001_ $$aTamimi, Rulla M$$b134 000147186 7001_ $$aTaylor, Jack A$$b135 000147186 7001_ $$aThöne, Kathrin$$b136 000147186 7001_ $$aTroester, Melissa A$$b137 000147186 7001_ $$aTruong, Thérèse$$b138 000147186 7001_ $$aVachon, Celine M$$b139 000147186 7001_ $$avan Ongeval, Chantal$$b140 000147186 7001_ $$avan Veen, Elke M$$b141 000147186 7001_ $$aWagner, Philippe$$b142 000147186 7001_ $$aWeinberg, Clarice R$$b143 000147186 7001_ $$aWildiers, Hans$$b144 000147186 7001_ $$aWillett, Walter$$b145 000147186 7001_ $$aWinham, Stacey J$$b146 000147186 7001_ $$aWolk, Alicja$$b147 000147186 7001_ $$aYang, Xiaohong R$$b148 000147186 7001_ $$aZheng, Wei$$b149 000147186 7001_ $$aZiogas, Argyrios$$b150 000147186 773__ $$0PERI:(DE-600)1494592-7$$a10.1093/ije/dyz193$$gp. dyz193$$n1$$p216-232$$tInternational journal of epidemiology$$v49$$x1464-3685$$y2020 000147186 909CO $$ooai:inrepo02.dkfz.de:147186$$pVDB 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6b04712f3afe72044d496a25505cb1ea$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0$$aDeutsches Krebsforschungszentrum$$b20$$kDKFZ 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b31$$kDKFZ 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aDeutsches Krebsforschungszentrum$$b38$$kDKFZ 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b$$aDeutsches Krebsforschungszentrum$$b72$$kDKFZ 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)bce1fdec5ce564e2666156d96aeabec9$$aDeutsches Krebsforschungszentrum$$b85$$kDKFZ 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aDeutsches Krebsforschungszentrum$$b86$$kDKFZ 000147186 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aDeutsches Krebsforschungszentrum$$b124$$kDKFZ 000147186 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0 000147186 9141_ $$y2020 000147186 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz 000147186 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline 000147186 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database 000147186 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central 000147186 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bINT J EPIDEMIOL : 2017 000147186 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS 000147186 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search 000147186 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC 000147186 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List 000147186 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index 000147186 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection 000147186 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded 000147186 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine 000147186 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences 000147186 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews 000147186 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bINT J EPIDEMIOL : 2017 000147186 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x0 000147186 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x1 000147186 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x2 000147186 9201_ $$0I:(DE-He78)C055-20160331$$kC055$$lC055 Genomische Epidemiologie$$x3 000147186 9201_ $$0I:(DE-He78)B072-20160331$$kB072$$lB072 Molekulargenetik des Mammakarzinoms$$x4 000147186 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x5 000147186 9200_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x0 000147186 980__ $$ajournal 000147186 980__ $$aVDB 000147186 980__ $$aI:(DE-He78)C020-20160331 000147186 980__ $$aI:(DE-He78)C070-20160331 000147186 980__ $$aI:(DE-He78)C120-20160331 000147186 980__ $$aI:(DE-He78)C055-20160331 000147186 980__ $$aI:(DE-He78)B072-20160331 000147186 980__ $$aI:(DE-He78)HD01-20160331 000147186 980__ $$aUNRESTRICTED