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@ARTICLE{Kapoor:147186,
      author       = {P. M. Kapoor$^*$ and S. Lindström and S. Behrens$^*$ and
                      X. Wang and K. Michailidou and M. K. Bolla and Q. Wang and
                      J. Dennis and A. M. Dunning and P. D. P. Pharoah and M. K.
                      Schmidt and P. Kraft and M. García-Closas and D. F. Easton
                      and R. L. Milne and J. Chang-Claude$^*$ and T. Ahearn and I.
                      L. Andrulis and H. Anton-Culver and V. Arndt$^*$ and K. J.
                      Aronson and P. L. Auer and A. Augustinsson and L. E. B.
                      Freeman and M. W. Beckmann and J. Benitez and L. Bernstein
                      and T. Berrandou and S. E. Bojesen and H. Brauch and H.
                      Brenner$^*$ and I. W. Brock and A. Broeks and A.
                      Brooks-Wilson and K. Butterbach and Q. Cai and D. Campa and
                      F. Canzian$^*$ and B. D. Carter and J. E. Castelao and S. J.
                      Chanock and G. Chenevix-Trench and T. D. Cheng and C. L.
                      Clarke and E. Cordina-Duverger and F. J. Couch and A. Cox
                      and S. S. Cross and K. Czene and J. Y. Dai and G. S. Dite
                      and H. S. Earp and A. H. Eliassen and M. Eriksson and D. G.
                      Evans and P. A. Fasching and J. Figueroa and H. Flyger and
                      L. Fritschi and M. Gabrielson and M. Gago-Dominguez and S.
                      M. Gapstur and M. M. Gaudet and G. G. Giles and A.
                      González-Neira and A. Grundy and P. Guénel and L. Haeberle
                      and C. A. Haiman and N. Håkansson and P. Hall and U.
                      Hamann$^*$ and S. E. Hankinson and E. F. Harkness and T.
                      Harstad and W. He and J. Heyworth and R. N. Hoover and J. L.
                      Hopper and K. Humphreys and D. J. Hunter and P. I. Marrón
                      and E. M. John and M. E. Jones and A. Jung$^*$ and R.
                      Kaaks$^*$ and R. Keeman and C. M. Kitahara and Y.-D. Ko and
                      S. Koutros and U. Krüger and D. Lambrechts and L. L.
                      Marchand and E. Lee and F. Lejbkowicz and M. Linet and J.
                      Lissowska and A. Llaneza and W.-Y. Lo and E. Makalic and M.
                      E. Martinez and T. Maurer and V. M. Muñoz-Garzon and S. L.
                      Neuhausen and P. Neven and W. G. Newman and S. F. Nielsen
                      and B. G. Nordestgaard and A. Norman and K. M. O'Brien and
                      A. F. Olshan and J. E. Olson and H. Olsson and N. Orr and C.
                      M. Perou and M. Pinchev and R. Prentice and G. Rennert and
                      H. S. Rennert and K. J. Ruddy and D. P. Sandler and M. O.
                      Schneider and M. J. Schoemaker and B. Schöttker$^*$ and R.
                      J. Scott and C. Scott and M. E. Sherman and M. J. Shrubsole
                      and X.-O. Shu and M. C. Southey and J. J. Spinelli and J.
                      Stone and A. J. Swerdlow and R. M. Tamimi and J. A. Taylor
                      and K. Thöne and M. A. Troester and T. Truong and C. M.
                      Vachon and C. van Ongeval and E. M. van Veen and P. Wagner
                      and C. R. Weinberg and H. Wildiers and W. Willett and S. J.
                      Winham and A. Wolk and X. R. Yang and W. Zheng and A.
                      Ziogas},
      collaboration = {B. C. A. Consortium},
      title        = {{A}ssessment of interactions between 205 breast cancer
                      susceptibility loci and 13 established risk factors in
                      relation to breast cancer risk, in the {B}reast {C}ancer
                      {A}ssociation {C}onsortium.},
      journal      = {International journal of epidemiology},
      volume       = {49},
      number       = {1},
      issn         = {1464-3685},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2019-02322},
      pages        = {216-232},
      year         = {2020},
      note         = {2020 Feb 1;49(1):216-232#EA:C020#},
      abstract     = {Previous gene-environment interaction studies of breast
                      cancer risk have provided sparse evidence of interactions.
                      Using the largest available dataset to date, we performed a
                      comprehensive assessment of potential effect modification of
                      205 common susceptibility variants by 13 established breast
                      cancer risk factors, including replication of previously
                      reported interactions.Analyses were performed using 28 176
                      cases and 32 209 controls genotyped with iCOGS array and
                      44 109 cases and 48 145 controls genotyped using OncoArray
                      from the Breast Cancer Association Consortium (BCAC).
                      Gene-environment interactions were assessed using
                      unconditional logistic regression and likelihood ratio tests
                      for breast cancer risk overall and by estrogen-receptor (ER)
                      status. Bayesian false discovery probability was used to
                      assess the noteworthiness of the meta-analysed
                      array-specific interactions.Noteworthy evidence of
                      interaction at $≤1\%$ prior probability was observed for
                      three single nucleotide polymorphism (SNP)-risk factor
                      pairs. SNP rs4442975 was associated with a greater reduction
                      of risk of ER-positive breast cancer [odds ratio (OR)int =
                      0.85 (0.78-0.93), Pint = 2.8 x 10-4] and overall breast
                      cancer [ORint = 0.85 (0.78-0.92), Pint = 7.4 x 10-5) in
                      current users of estrogen-progesterone therapy compared with
                      non-users. This finding was supported by replication using
                      OncoArray data of the previously reported interaction
                      between rs13387042 (r2 = 0.93 with rs4442975) and current
                      estrogen-progesterone therapy for overall disease (Pint =
                      0.004). The two other interactions suggested stronger
                      associations between SNP rs6596100 and ER-negative breast
                      cancer with increasing parity and younger age at first
                      birth.Overall, our study does not suggest strong effect
                      modification of common breast cancer susceptibility variants
                      by established risk factors.},
      cin          = {C020 / C070 / C120 / C055 / B072 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)C055-20160331 /
                      I:(DE-He78)B072-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31605532},
      doi          = {10.1093/ije/dyz193},
      url          = {https://inrepo02.dkfz.de/record/147186},
}