%0 Journal Article
%A Gao, Xin
%A Xuan, Yang
%A Benner, Axel
%A Anusruti, Ankita
%A Brenner, Hermann
%A Schöttker, Ben
%T Nitric Oxide Metabolites and Lung Cancer Incidence: A Matched Case-Control Study Nested in the ESTHER Cohort.
%J Oxidative medicine and cellular longevity
%V 2019
%@ 1942-0994
%C Austin, Tex.
%I Landes Bioscience
%M DKFZ-2019-02324
%P 6470950
%D 2019
%X Studies suggest that nitric oxide (NO) may have a possible role in lung carcinogenesis. This study is aimed to evaluate the association of the NO metabolites, namely, nitrite and nitrate, with lung cancer incidence. We conducted a matched case-control study (n = 245 incident lung cancer cases and n = 735 controls) based on the German ESTHER cohort (n = 9,940). Controls were matched to cases on age, sex, smoking status (never/former/current smoking), and pack-years of smoking. The sum of nitrite and nitrate was measured in urine samples using a colorimetric assay and was standardized for renal function by urinary creatinine. Conditional logistic regression models, adjusted for lifestyle factors, asthma prevalence, and family history of lung cancer, were used to estimate odds ratios (ORs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31565153
%2 pmc:PMC6745103
%R 10.1155/2019/6470950
%U https://inrepo02.dkfz.de/record/147188