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@ARTICLE{Hu:147204,
      author       = {C. Hu and B. Schöttker$^*$ and N. Venisse and F. Limousi
                      and P. J. Saulnier and M. Albouy-Llaty and A. Dupuis and H.
                      Brenner$^*$ and V. Migeot and S. Hadjadj},
      title        = {{B}isphenol {A}, {C}hlorinated {D}erivatives of {B}isphenol
                      {A} and {O}ccurrence of {M}yocardial {I}nfarction in
                      {P}atients with {T}ype 2 {D}iabetes: {N}ested
                      {C}ase-{C}ontrol {S}tudies in {T}wo {E}uropean {C}ohorts.},
      journal      = {Environmental science $\&$ technology},
      volume       = {53},
      number       = {16},
      issn         = {1520-5851},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Society},
      reportid     = {DKFZ-2019-02330},
      pages        = {9876 - 9883},
      year         = {2019},
      abstract     = {A positive association between Bisphenol A (BPA) exposure
                      and coronary heart disease has been shown, but not in
                      patients with type 2 diabetes (T2D). During the treatment of
                      drinking water, chlorination leads to the formation of
                      chlorinated derivatives of Bisphenol A (ClxBPA), that have
                      higher estrogenic activity than BPA. No evidence exists for
                      a relationship between exposure to ClxBPA and myocardial
                      infarction in patients with T2D. The objective of this study
                      was to evaluate the relationship between exposure to BPA,
                      ClxBPA and the occurrence of myocardial infarction (MI) in
                      patients with T2D. Two nested case-control studies in two
                      independent European cohorts were performed. Each case with
                      incident MI during follow-up was matched to one control on
                      age, sex, and personal cardiovascular history in the same
                      cohort. Association between baseline urine concentrations of
                      BPA and of ClxBPA and incident MI was determined. Exposure
                      to BPA was $31\%$ in the ESTHER cohort and $18\%$ in the
                      SURDIAGENE cohort. In a meta-analysis of the two studies,
                      occurrence of MI was significantly associated with urine BPA
                      detection: adjusted OR = 1.97 (1.05-3.70), p = 0.04.
                      Exposure to ClxBPA significantly differed in the SURDIAGENE
                      and ESTHER studies: $24\%$ and $8\%,$ respectively (p =
                      0.0003). It was very strongly associated with MI in the
                      SURDIAGENE cohort with an adjusted odds ratio (OR) of 14.15
                      (2.77-72.40) but this association was not replicated in the
                      ESTHER study: adjusted OR: 0.17 (0.02-1.23). Whether these
                      results may be explained by different water chlorination
                      processes in France and Germany, resulting in different
                      ClxBPA exposure levels, requires further investigation.},
      cin          = {C070 / C120},
      ddc          = {333.7},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31310111},
      doi          = {10.1021/acs.est.9b02963},
      url          = {https://inrepo02.dkfz.de/record/147204},
}