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000147212 1001_ $$0P:(DE-He78)3877ae274d0271d6bf311bb46539f013$$aDelecluse, Susanne$$b0$$eFirst author$$udkfz
000147212 245__ $$aSpontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs.
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000147212 520__ $$aThe Epstein-Barr virus (EBV) induces B-cell proliferation with high efficiency through expression of latent proteins and microRNAs. This process takes place in vivo soon after infection, presumably to expand the virus reservoir, but can also induce pathologies, e.g. an infectious mononucleosis (IM) syndrome after primary infection or a B-cell lymphoproliferation in immunosuppressed individuals. In this paper, we investigated the growth characteristics of EBV-infected B-cells isolated from transplant recipients or patients with IM. We found that these cells grew and withstood apoptosis at highly variable rates, suggesting that the expansion rate of the infected B-cells widely varies between individuals, thereby influencing the size of the B-cell reservoir and the ability to form tumors in infected individuals. All viruses investigated were type 1 and genetically close to western strains. EBV-infected B-cells expressed the transforming EBV latent genes and microRNAs (miRNAs) at variable levels. We found that the B-cell growth rates positively correlated with the BHRF1 miRNA levels. Comparative studies showed that infected B-cells derived from transplant recipients with iEBVL on average expressed higher levels of EBV miR-BHRF1 miRNAs and grew more rapidly than B-cells from IM patients, suggesting infection by more transforming viruses. Altogether, these findings suggest that EBV infection has a highly variable impact on the B-cell compartment that probably reflects the genetic diversity of both the virus and the host. It also demonstrates the unexpected finding that B-cells from different individuals can grow at different speed under the influence of the same virus infection.
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000147212 7001_ $$0P:(DE-HGF)0$$aYu, Jiyang$$b1
000147212 7001_ $$0P:(DE-He78)944cafd16d8f74f63b6b7039c6407dc5$$aBernhardt, Katharina$$b2
000147212 7001_ $$0P:(DE-He78)8e35fdc54ac8a2edd210217ec7de6475$$aHaar, Janina$$b3
000147212 7001_ $$0P:(DE-He78)27152949302e3bd0d681a6f0548912b9$$aPoirey, Remy$$b4$$udkfz
000147212 7001_ $$0P:(DE-He78)33beb55034049b5d9833135ad1e0e3d2$$aTsai, Ming-Han$$b5
000147212 7001_ $$0P:(DE-He78)cb907534b02fbd117b245259355afba5$$aKiblawi, Rama$$b6
000147212 7001_ $$0P:(DE-He78)bb6a7a70f976eb8df1769944bf913596$$aKopp-Schneider, Annette$$b7$$udkfz
000147212 7001_ $$aSchnitzler, Paul$$b8
000147212 7001_ $$aZeier, Martin$$b9
000147212 7001_ $$aDreger, Peter$$b10
000147212 7001_ $$aWuchter, Patrick$$b11
000147212 7001_ $$aBulut, Olcay Cem$$b12
000147212 7001_ $$aBehrends, Uta$$b13
000147212 7001_ $$0P:(DE-He78)25d3c74b949988c637571e696fc04b25$$aDelecluse, Henri-Jacques$$b14$$eLast author$$udkfz
000147212 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0222847$$gVol. 14, no. 9, p. e0222847 -$$n9$$pe0222847 -$$tPLOS ONE$$v14$$x1932-6203$$y2019
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