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@ARTICLE{Delecluse:147212,
      author       = {S. Delecluse$^*$ and J. Yu$^*$ and K. Bernhardt$^*$ and J.
                      Haar$^*$ and R. Poirey$^*$ and M.-H. Tsai$^*$ and R.
                      Kiblawi$^*$ and A. Kopp-Schneider$^*$ and P. Schnitzler and
                      M. Zeier and P. Dreger and P. Wuchter and O. C. Bulut and U.
                      Behrends and H.-J. Delecluse$^*$},
      title        = {{S}pontaneous lymphoblastoid cell lines from patients with
                      {E}pstein-{B}arr virus infection show highly variable
                      proliferation characteristics that correlate with the
                      expression levels of viral micro{RNA}s.},
      journal      = {PLOS ONE},
      volume       = {14},
      number       = {9},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DKFZ-2019-02338},
      pages        = {e0222847 -},
      year         = {2019},
      abstract     = {The Epstein-Barr virus (EBV) induces B-cell proliferation
                      with high efficiency through expression of latent proteins
                      and microRNAs. This process takes place in vivo soon after
                      infection, presumably to expand the virus reservoir, but can
                      also induce pathologies, e.g. an infectious mononucleosis
                      (IM) syndrome after primary infection or a B-cell
                      lymphoproliferation in immunosuppressed individuals. In this
                      paper, we investigated the growth characteristics of
                      EBV-infected B-cells isolated from transplant recipients or
                      patients with IM. We found that these cells grew and
                      withstood apoptosis at highly variable rates, suggesting
                      that the expansion rate of the infected B-cells widely
                      varies between individuals, thereby influencing the size of
                      the B-cell reservoir and the ability to form tumors in
                      infected individuals. All viruses investigated were type 1
                      and genetically close to western strains. EBV-infected
                      B-cells expressed the transforming EBV latent genes and
                      microRNAs (miRNAs) at variable levels. We found that the
                      B-cell growth rates positively correlated with the BHRF1
                      miRNA levels. Comparative studies showed that infected
                      B-cells derived from transplant recipients with iEBVL on
                      average expressed higher levels of EBV miR-BHRF1 miRNAs and
                      grew more rapidly than B-cells from IM patients, suggesting
                      infection by more transforming viruses. Altogether, these
                      findings suggest that EBV infection has a highly variable
                      impact on the B-cell compartment that probably reflects the
                      genetic diversity of both the virus and the host. It also
                      demonstrates the unexpected finding that B-cells from
                      different individuals can grow at different speed under the
                      influence of the same virus infection.},
      cin          = {F100 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)F100-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31568538},
      pmc          = {pmc:PMC6768455},
      doi          = {10.1371/journal.pone.0222847},
      url          = {https://inrepo02.dkfz.de/record/147212},
}