TY  - JOUR
AU  - Luft, Thomas
AU  - Benner, Axel
AU  - Terzer, Tobias
AU  - Jodele, Sonata
AU  - Dandoy, Christopher E
AU  - Storb, Rainer
AU  - Kordelas, Lambros
AU  - Beelen, Dietrich
AU  - Gooley, Ted
AU  - Sandmaier, Brenda M
AU  - Sorror, Mohamed
AU  - Zeisbrich, Markus
AU  - Radujkovic, Aleksandar
AU  - Dreger, Peter
AU  - Penack, Olaf
TI  - EASIX and mortality after allogeneic stem cell transplantation.
JO  - Bone marrow transplantation
VL  - 55
IS  - 3
SN  - 0268-3369
CY  - London
PB  - Nature Publishing Group55086
M1  - DKFZ-2019-02342
SP  - 553-561
PY  - 2020
N1  - 2020 Mar;55(3):553-561
AB  - Allogeneic stem cell transplantation (alloSCT) is an effective immunotherapy in patients with hematological malignancies. Endothelial dysfunction was linked to major complications after alloSCT. We asked the question if the 'Endothelial Activation and Stress Index' (EASIX; [(creatinine × LDH) ÷ thrombocytes]) can predict mortality after alloSCT. We performed a retrospective cohort analysis in five alloSCT centers in the USA and Germany. EASIX was assessed prior to conditioning (EASIX-pre) and correlated with mortality in 755 patients of a training cohort in multivariable models. The predictive model established in the training cohort was validated in 1267 adult allo-recipients. Increasing EASIX-pre predicted lower overall survival (OS) after alloSCT, and successful model validation was achieved for the validation cohort. We found that EASIX-pre predicts OS irrespective of established scores. Moreover, EASIX-pre was also a significant prognostic factor for transplant-associated microangiopathy. Finally, EASIX-pre correlated with biomarkers of endothelial homeostasis such as CXCL8, interleukin-18, and insulin-like-growth-factor-1 serum levels. This study establishes EASIX-pre based on a standard laboratory biomarker panel as a predictor of individual risk of mortality after alloSCT independently from established clinical criteria.
LB  - PUB:(DE-HGF)16
C6  - pmid:31558788
DO  - DOI:10.1038/s41409-019-0703-1
UR  - https://inrepo02.dkfz.de/record/147216
ER  -