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@ARTICLE{Luft:147216,
      author       = {T. Luft and A. Benner$^*$ and T. Terzer$^*$ and S. Jodele
                      and C. E. Dandoy and R. Storb and L. Kordelas and D. Beelen
                      and T. Gooley and B. M. Sandmaier and M. Sorror and M.
                      Zeisbrich and A. Radujkovic and P. Dreger and O. Penack},
      title        = {{EASIX} and mortality after allogeneic stem cell
                      transplantation.},
      journal      = {Bone marrow transplantation},
      volume       = {55},
      number       = {3},
      issn         = {0268-3369},
      address      = {London},
      publisher    = {Nature Publishing Group55086},
      reportid     = {DKFZ-2019-02342},
      pages        = {553-561},
      year         = {2020},
      note         = {2020 Mar;55(3):553-561},
      abstract     = {Allogeneic stem cell transplantation (alloSCT) is an
                      effective immunotherapy in patients with hematological
                      malignancies. Endothelial dysfunction was linked to major
                      complications after alloSCT. We asked the question if the
                      'Endothelial Activation and Stress Index' (EASIX;
                      [(creatinine × LDH) ÷ thrombocytes]) can predict
                      mortality after alloSCT. We performed a retrospective cohort
                      analysis in five alloSCT centers in the USA and Germany.
                      EASIX was assessed prior to conditioning (EASIX-pre) and
                      correlated with mortality in 755 patients of a training
                      cohort in multivariable models. The predictive model
                      established in the training cohort was validated in 1267
                      adult allo-recipients. Increasing EASIX-pre predicted lower
                      overall survival (OS) after alloSCT, and successful model
                      validation was achieved for the validation cohort. We found
                      that EASIX-pre predicts OS irrespective of established
                      scores. Moreover, EASIX-pre was also a significant
                      prognostic factor for transplant-associated microangiopathy.
                      Finally, EASIX-pre correlated with biomarkers of endothelial
                      homeostasis such as CXCL8, interleukin-18, and
                      insulin-like-growth-factor-1 serum levels. This study
                      establishes EASIX-pre based on a standard laboratory
                      biomarker panel as a predictor of individual risk of
                      mortality after alloSCT independently from established
                      clinical criteria.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31558788},
      doi          = {10.1038/s41409-019-0703-1},
      url          = {https://inrepo02.dkfz.de/record/147216},
}