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@ARTICLE{Jkel:147231,
      author       = {O. Jäkel$^*$},
      title        = {{P}hysical advantages of particles: protons and light
                      ions.},
      journal      = {The British journal of radiology},
      volume       = {93},
      number       = {1107},
      issn         = {1748-880X},
      address      = {London},
      publisher    = {Inst.},
      reportid     = {DKFZ-2019-02357},
      pages        = {20190428 -},
      year         = {2020},
      note         = {2020 Mar;93(1107):20190428#LA:E040#},
      abstract     = {Proton and ion beam therapy has been introduced in the
                      Lawrence Berkeley National Laboratory in the mid-1950s, when
                      protons and helium ions have been used for the first time to
                      treat patients. Starting in 1972, the scientists at Berkeley
                      also were the first to use heavier ions (carbon, oxygen,
                      neon, silicon and argon ions). The first clinical ion beam
                      facility opened in 1994 in Japan and since then, the
                      interest in radiotherapy with light ion beams has been
                      increasing slowly but steadily, with 13 centers in clinical
                      operation in 2019. All these centers are using carbon ions
                      for clinical application.The article outlines the
                      differences in physical properties of various light ions as
                      compared to protons in view of the application in
                      radiotherapy. These include the energy loss and depth dose
                      properties, multiple scattering, range straggling and
                      nuclear fragmentation. In addition, the paper discusses
                      differences arising from energy loss and linear energy
                      transfer with respect to their biological effects.Moreover,
                      the paper reviews briefly the existing clinical data
                      comparing protons and ions and outlines the future
                      perspectives for the clinical use of ions like oxygen and
                      helium.},
      subtyp        = {Review Article},
      cin          = {E040},
      ddc          = {610},
      cid          = {I:(DE-He78)E040-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31556333},
      doi          = {10.1259/bjr.20190428},
      url          = {https://inrepo02.dkfz.de/record/147231},
}