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@ARTICLE{Wedekind:147241,
      author       = {R. Wedekind and P. Keski-Rahkonen and N. Robinot and V.
                      Viallon and P. Ferrari and E. Engel and M.-C. Boutron-Ruault
                      and Y. Mahamat-Saleh and F. R. Mancini and T. Kühn$^*$ and
                      T. Johnson$^*$ and H. Boeing and M. Bergmann and A.
                      Karakatsani and A. Trichopoulou and H. Peppa and C. Agnoli
                      and M. Santucci de Magistris and D. Palli and C. Sacerdote
                      and R. Tumino and M. J. Gunter and I. Huybrechts and A.
                      Scalbert},
      title        = {{S}yringol metabolites as new biomarkers for smoked meat
                      intake.},
      journal      = {The American journal of clinical nutrition},
      volume       = {110},
      number       = {6},
      issn         = {1938-3207},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2019-02367},
      pages        = {1424-1433},
      year         = {2019},
      note         = {2019 Dec 1;110(6):1424-1433},
      abstract     = {Processed meat intake is associated with a higher risk of
                      colorectal and stomach cancers, coronary artery disease, and
                      type 2 diabetes and with higher mortality, but the
                      estimation of intake of different processed meat products in
                      this heterogeneous food group in epidemiological studies
                      remains challenging.This work aimed at identifying novel
                      biomarkers for processed meat intake using metabolomics.An
                      untargeted, multi-tiered metabolomics approach based on
                      LC-MS was applied to 33 meat products digested in vitro and
                      secondly to urine and plasma samples from a randomized
                      crossover dietary intervention in which 12 volunteers
                      consumed successively 3 processed meat products (bacon,
                      salami, and hot dog) and 2 other foods used as controls,
                      over 3 consecutive days. The putative biomarkers were then
                      measured in urine from 474 subjects from the European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      cross-sectional study for which detailed 24-h dietary
                      recalls and FFQs were available.Syringol and 4 derivatives
                      of syringol were found to be characteristic of in vitro
                      digests of smoked meat products. The same compounds present
                      as sulfate esters in urine increased at 2 and 12 h after
                      consumption of smoked meat products (hot dog, bacon) in the
                      intervention study. The same syringol sulfates were also
                      positively associated with recent or habitual consumption of
                      smoked meat products in urine samples from participants of
                      the EPIC cross-sectional study. These compounds showed good
                      discriminative ability for smoked meat intake with receiver
                      operator characteristic areas under the curve ranging from
                      0.78 to 0.86 and 0.74 to 0.79 for short-term and habitual
                      intake, respectively.Four novel syringol sulfates were
                      identified as potential biomarkers of smoked meat intake and
                      may be used to improve assessment of smoked meat intake in
                      epidemiological studies. This trial was registered at
                      clinicaltrials.gov as NCT03354130.},
      cin          = {C020},
      ddc          = {570},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31559413},
      doi          = {10.1093/ajcn/nqz222},
      url          = {https://inrepo02.dkfz.de/record/147241},
}