%0 Journal Article
%A Wefers, Annika
%A Stichel, Damian
%A Schrimpf, Daniel
%A Coras, Roland
%A Pages, Mélanie
%A Tauziède-Espariat, Arnault
%A Varlet, Pascale
%A Schwarz, Daniel
%A Söylemezoglu, Figen
%A Pohl, Ute
%A Pimentel, José
%A Meyer, Jochen
%A Hewer, Ekkehard
%A Japp, Anna
%A Joshi, Abhijit
%A Reuss, David E
%A Reinhardt, Annekathrin
%A Sievers, Philipp
%A Casalini, Maria Belen
%A Ebrahimi, Azadeh
%A Huang, Kristin
%A Koelsche, Christian
%A Low, Hu Liang
%A Rebelo, Olinda
%A Marnoto, Dina
%A Becker, Albert J
%A Staszewski, Ori
%A Mittelbronn, Michel
%A Hasselblatt, Martin
%A Schittenhelm, Jens
%A Cheesman, Edmund
%A de Oliveira, Ricardo Santos
%A Queiroz, Rosane Gomes P
%A Valera, Elvis Terci
%A Hans, Volkmar H
%A Korshunov, Andrey
%A Olar, Adriana
%A Ligon, Keith L
%A Pfister, Stefan
%A Jaunmuktane, Zane
%A Brandner, Sebastian
%A Tatevossian, Ruth G
%A Ellison, David W
%A Jacques, Thomas S
%A Honavar, Mrinalini
%A Aronica, Eleonora
%A Thom, Maria
%A Sahm, Felix
%A von Deimling, Andreas
%A Jones, David
%A Blumcke, Ingmar
%A Capper, David
%T Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.
%J Acta neuropathologica
%V 139
%N 1
%@ 1432-0533
%C Heidelberg
%I Springer
%M DKFZ-2019-02372
%P 193-209
%D 2020
%Z 2020 Jan;139(1):193-209#EA:B300#
%X The 'isomorphic subtype of diffuse astrocytoma' was identified histologically in 2004 as a supratentorial, highly differentiated glioma with low cellularity, low proliferation and focal diffuse brain infiltration. Patients typically had seizures since childhood and all were operated on as adults. To define the position of these lesions among brain tumours, we histologically, molecularly and clinically analysed 26 histologically prototypical isomorphic diffuse gliomas. Immunohistochemically, they were GFAP-positive, MAP2-, OLIG2- and CD34-negative, nuclear ATRX-expression was retained and proliferation was low. All 24 cases sequenced were IDH-wildtype. In cluster analyses of DNA methylation data, isomorphic diffuse gliomas formed a group clearly distinct from other glial/glio-neuronal brain tumours and normal hemispheric tissue, most closely related to paediatric MYB/MYBL1-altered diffuse astrocytomas and angiocentric gliomas. Half of the isomorphic diffuse gliomas had copy number alterations of MYBL1 or MYB (13/25, 52
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31563982
%R 10.1007/s00401-019-02078-w
%U https://inrepo02.dkfz.de/record/147249