%0 Journal Article
%A Jaskulski, Stefanie
%A Jung, Audrey Ying-Chee
%A Huebner, Marianne
%A Poschet, Gernot
%A Hell, Rüdiger
%A Hüsing, Anika
%A Gonzalez-Maldonado, Sandra
%A Behrens, Sabine
%A Obi, Nadia
%A Becher, Heiko
%A Chang-Claude, Jenny
%T Prognostic associations of circulating phytoestrogens and biomarker changes in long-term survivors of postmenopausal breast cancer.
%J Nutrition and cancer
%V 72
%N 7
%@ 1532-7914
%C New York, NY
%I Routledge, Taylor & Francis Group
%M DKFZ-2019-02396
%P 1155-1169
%D 2020
%Z 2020;72(7):1155-1169#EA:C020#LA:C020#
%X Lignans are associated with improved postmenopausal breast cancer (BC) survival, but whether these associations, particularly with enterolactone (major lignan metabolite), persist over time is unclear. Little is known about other phytoestrogens on prognosis in long-term survivors. The study examines associations of prognosis with 1) circulating postdiagnosis enterolactone, 2) eight circulating phytoestrogen metabolites, and 3) changes in enterolactone and genistein. In a German cohort of 2,105 postmenopausal BC patients with blood samples collected at recruitment 2002-2005 (baseline) and re-interview in 2009 (follow-up), delay-entry Cox proportional hazards regression was used. Landmark analysis showed that circulating enterolactone (log2) associations with 5-year survival changed over time, with strongest hazard ratios of 0.89 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31617773
%R 10.1080/01635581.2019.1672762
%U https://inrepo02.dkfz.de/record/147273