TY  - JOUR
AU  - Jaskulski, Stefanie
AU  - Jung, Audrey Ying-Chee
AU  - Huebner, Marianne
AU  - Poschet, Gernot
AU  - Hell, Rüdiger
AU  - Hüsing, Anika
AU  - Gonzalez-Maldonado, Sandra
AU  - Behrens, Sabine
AU  - Obi, Nadia
AU  - Becher, Heiko
AU  - Chang-Claude, Jenny
TI  - Prognostic associations of circulating phytoestrogens and biomarker changes in long-term survivors of postmenopausal breast cancer.
JO  - Nutrition and cancer
VL  - 72
IS  - 7
SN  - 1532-7914
CY  - New York, NY
PB  - Routledge, Taylor & Francis Group
M1  - DKFZ-2019-02396
SP  - 1155-1169
PY  - 2020
N1  - 2020;72(7):1155-1169#EA:C020#LA:C020#
AB  - Lignans are associated with improved postmenopausal breast cancer (BC) survival, but whether these associations, particularly with enterolactone (major lignan metabolite), persist over time is unclear. Little is known about other phytoestrogens on prognosis in long-term survivors. The study examines associations of prognosis with 1) circulating postdiagnosis enterolactone, 2) eight circulating phytoestrogen metabolites, and 3) changes in enterolactone and genistein. In a German cohort of 2,105 postmenopausal BC patients with blood samples collected at recruitment 2002-2005 (baseline) and re-interview in 2009 (follow-up), delay-entry Cox proportional hazards regression was used. Landmark analysis showed that circulating enterolactone (log2) associations with 5-year survival changed over time, with strongest hazard ratios of 0.89 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:31617773
DO  - DOI:10.1080/01635581.2019.1672762
UR  - https://inrepo02.dkfz.de/record/147273
ER  -