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000147318 041__ $$aeng
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000147318 1001_ $$aHarms, Laura M$$b0
000147318 245__ $$aPlasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
000147318 260__ $$aCambridge$$bCambridge Univ. Press$$c2020
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000147318 500__ $$a2020 Jan 28;123(2):198-208
000147318 520__ $$aExperimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent, and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterize the association between plasma concentrations of 35 polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis the odds and 95% confidence intervals (CI-s) of elevated serum hsCRP (>3 mg/L) were calculated within quartiles and per standard deviation (SD) higher level of plasma polyphenol concentrations. In multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per SD) was associated with 29% lower odds of elevated hsCRP (95% CI: 50%-1%). In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR= 0.66, 95%CI 0.46-0.96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR=0.58, 95%CI 0.39-0.86), 3,4-dihydroxyphenylpropionic acid (OR= 0.63, 95% CI 0.46-0.87), ferulic acid (OR= 0.65, 95%CI 0.44-0.96), and caffeic acid (OR= 0.69, 95%CI 0.51-0.93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR= 0.67, 95%CI 0.48-0.93). This study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.
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000147318 7001_ $$aScalbert, Augustin$$b1
000147318 7001_ $$00000-0002-6236-6804$$aZamora-Ros, Raul$$b2
000147318 7001_ $$aRinaldi, Sabina$$b3
000147318 7001_ $$aJenab, Mazda$$b4
000147318 7001_ $$aMurphy, Neil$$b5
000147318 7001_ $$aAchaintre, David$$b6
000147318 7001_ $$aTjønneland, Anne$$b7
000147318 7001_ $$aOlsen, Anja$$b8
000147318 7001_ $$aOvervad, Kim$$b9
000147318 7001_ $$aMancini, Francesca Romana$$b10
000147318 7001_ $$aMahamat-Saleh, Yahya$$b11
000147318 7001_ $$aBoutron-Ruault, Marie-Christine$$b12
000147318 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b13$$udkfz
000147318 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b14$$udkfz
000147318 7001_ $$aTrichopoulou, Antonia$$b15
000147318 7001_ $$aMartimianaki, Georgia$$b16
000147318 7001_ $$aKarakatsani, Anna$$b17
000147318 7001_ $$aPalli, Domenico$$b18
000147318 7001_ $$aPanico, Salvatore$$b19
000147318 7001_ $$aSieri, Sabina$$b20
000147318 7001_ $$aTumino, Rosario$$b21
000147318 7001_ $$aSacerdote, Carlotta$$b22
000147318 7001_ $$aBueno-de-Mesquita, Bas$$b23
000147318 7001_ $$aVermeulen, Roel C H$$b24
000147318 7001_ $$aWeiderpass, Elisabete$$b25
000147318 7001_ $$aNøst, Therese Haugdahl$$b26
000147318 7001_ $$aLasheras, Cristina$$b27
000147318 7001_ $$aRodríguez-Barranco, Miguel$$b28
000147318 7001_ $$aHuerta, José María$$b29
000147318 7001_ $$aBarricarte, Aurelio$$b30
000147318 7001_ $$aDorronsoro, Miren$$b31
000147318 7001_ $$aHultdin, Johan$$b32
000147318 7001_ $$aSchmidt, Julie A$$b33
000147318 7001_ $$aGunter, Marc$$b34
000147318 7001_ $$aRiboli, Elio$$b35
000147318 7001_ $$aAleksandrova, Krasimira$$b36
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