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@ARTICLE{Harms:147318,
      author       = {L. M. Harms and A. Scalbert and R. Zamora-Ros and S.
                      Rinaldi and M. Jenab and N. Murphy and D. Achaintre and A.
                      Tjønneland and A. Olsen and K. Overvad and F. R. Mancini
                      and Y. Mahamat-Saleh and M.-C. Boutron-Ruault and T.
                      Kühn$^*$ and V. Katzke$^*$ and A. Trichopoulou and G.
                      Martimianaki and A. Karakatsani and D. Palli and S. Panico
                      and S. Sieri and R. Tumino and C. Sacerdote and B.
                      Bueno-de-Mesquita and R. C. H. Vermeulen and E. Weiderpass
                      and T. H. Nøst and C. Lasheras and M. Rodríguez-Barranco
                      and J. M. Huerta and A. Barricarte and M. Dorronsoro and J.
                      Hultdin and J. A. Schmidt and M. Gunter and E. Riboli and K.
                      Aleksandrova},
      title        = {{P}lasma polyphenols associated with lower high-sensitivity
                      {C}-reactive protein concentrations: a cross-sectional study
                      within the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition ({EPIC}) cohort.},
      journal      = {British journal of nutrition},
      volume       = {123},
      number       = {2},
      issn         = {1475-2662},
      address      = {Cambridge},
      publisher    = {Cambridge Univ. Press},
      reportid     = {DKFZ-2019-02439},
      pages        = {198-208},
      year         = {2020},
      note         = {2020 Jan 28;123(2):198-208},
      abstract     = {Experimental studies have reported on the anti-inflammatory
                      properties of polyphenols. However, results from
                      epidemiological investigations have been inconsistent, and
                      especially studies using biomarkers for assessment of
                      polyphenol intake have been scant. We aimed to characterize
                      the association between plasma concentrations of 35
                      polyphenol compounds and low-grade systemic inflammation
                      state as measured by high-sensitivity C-reactive protein
                      (hsCRP). A cross-sectional data analysis was performed based
                      on 315 participants in the European Prospective
                      Investigation into Cancer and Nutrition cohort with
                      available measurements of plasma polyphenols and hsCRP. In
                      logistic regression analysis the odds and $95\%$ confidence
                      intervals (CI-s) of elevated serum hsCRP (>3 mg/L) were
                      calculated within quartiles and per standard deviation (SD)
                      higher level of plasma polyphenol concentrations. In
                      multivariable-adjusted model, the sum of plasma
                      concentrations of all polyphenols measured (per SD) was
                      associated with $29\%$ lower odds of elevated hsCRP $(95\%$
                      CI: $50\%-1\%).$ In the class of flavonoids, daidzein was
                      inversely associated with elevated hsCRP (OR= 0.66, $95\%CI$
                      0.46-0.96). Among phenolic acids, statistically significant
                      associations were observed for 3,5-dihydroxyphenylpropionic
                      acid (OR=0.58, $95\%CI$ 0.39-0.86),
                      3,4-dihydroxyphenylpropionic acid (OR= 0.63, $95\%$ CI
                      0.46-0.87), ferulic acid (OR= 0.65, $95\%CI$ 0.44-0.96), and
                      caffeic acid (OR= 0.69, $95\%CI$ 0.51-0.93). The odds of
                      elevated hsCRP were significantly reduced for hydroxytyrosol
                      (OR= 0.67, $95\%CI$ 0.48-0.93). This study showed that
                      polyphenol biomarkers are associated with lower odds of
                      elevated hsCRP. Whether diet rich in bioactive polyphenol
                      compounds could be an effective strategy to prevent or
                      modulate deleterious health effects of inflammation should
                      be addressed by further well-powered longitudinal studies.},
      cin          = {C020},
      ddc          = {570},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31583990},
      doi          = {10.1017/S0007114519002538},
      url          = {https://inrepo02.dkfz.de/record/147318},
}