TY  - JOUR
AU  - Jaju, A.
AU  - Hwang, E. I.
AU  - Kool, Marcel
AU  - Capper, David
AU  - Chavez, L.
AU  - Brabetz, Sebastian
AU  - Billups, C.
AU  - Li, Y.
AU  - Fouladi, M.
AU  - Packer, R. J.
AU  - Pfister, S. M.
AU  - Olson, J. M.
AU  - Heier, L. A.
TI  - MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial.
JO  - American journal of neuroradiology
VL  - 40
IS  - 11
SN  - 1936-959X
CY  - Oak Brook, Ill.
PB  - Soc.
M1  - DKFZ-2019-02455
SP  - 1796-1803
PY  - 2019
N1  - 40(11):1796-1803
AB  - Supratentorial primitive neuroectodermal tumors and pineoblastomas have traditionally been grouped together for treatment purposes. Molecular profiling of these tumors has revealed a number of distinct entities and has led to the term 'CNS-primitive neuroectodermal tumors' being removed from the 2016 World Health Organization classification. The purpose of this study was to describe the MR imaging findings of histologically diagnosed primitive neuroectodermal tumors and pineoblastomas and correlate them with molecular diagnoses and outcomes.Histologically diagnosed primitive neuroectodermal tumors and pineoblastomas were enrolled in this Children's Oncology Group Phase III trial, and molecular classification was retrospectively completed using DNA methylation profiling. MR imaging features were systematically studied and correlated with molecular diagnoses and survival.Of the 85 patients enrolled, 56 met the inclusion criteria, in whom 28 tumors were in pineal and 28 in nonpineal locations. Methylation profiling revealed a variety of diagnoses, including pineoblastomas (n = 27), high-grade gliomas (n = 17), embryonal tumors (n = 7), atypical teratoid/rhabdoid tumors (n = 3), and ependymomas (n = 2). Thus, 39
LB  - PUB:(DE-HGF)16
C6  - pmid:31601576
DO  - DOI:10.3174/ajnr.A6253
UR  - https://inrepo02.dkfz.de/record/147334
ER  -