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@ARTICLE{Jaju:147334,
      author       = {A. Jaju and E. I. Hwang and M. Kool$^*$ and D. Capper and
                      L. Chavez and S. Brabetz and C. Billups and Y. Li and M.
                      Fouladi and R. J. Packer and S. M. Pfister$^*$ and J. M.
                      Olson and L. A. Heier},
      title        = {{MRI} {F}eatures of {H}istologically {D}iagnosed
                      {S}upratentorial {P}rimitive {N}euroectodermal {T}umors and
                      {P}ineoblastomas in {C}orrelation with {M}olecular
                      {D}iagnoses and {O}utcomes: {A} {R}eport from the
                      {C}hildren's {O}ncology {G}roup {ACNS}0332 {T}rial.},
      journal      = {American journal of neuroradiology},
      volume       = {40},
      number       = {11},
      issn         = {1936-959X},
      address      = {Oak Brook, Ill.},
      publisher    = {Soc.},
      reportid     = {DKFZ-2019-02455},
      pages        = {1796-1803},
      year         = {2019},
      note         = {40(11):1796-1803},
      abstract     = {Supratentorial primitive neuroectodermal tumors and
                      pineoblastomas have traditionally been grouped together for
                      treatment purposes. Molecular profiling of these tumors has
                      revealed a number of distinct entities and has led to the
                      term 'CNS-primitive neuroectodermal tumors' being removed
                      from the 2016 World Health Organization classification. The
                      purpose of this study was to describe the MR imaging
                      findings of histologically diagnosed primitive
                      neuroectodermal tumors and pineoblastomas and correlate them
                      with molecular diagnoses and outcomes.Histologically
                      diagnosed primitive neuroectodermal tumors and
                      pineoblastomas were enrolled in this Children's Oncology
                      Group Phase III trial, and molecular classification was
                      retrospectively completed using DNA methylation profiling.
                      MR imaging features were systematically studied and
                      correlated with molecular diagnoses and survival.Of the 85
                      patients enrolled, 56 met the inclusion criteria, in whom 28
                      tumors were in pineal and 28 in nonpineal locations.
                      Methylation profiling revealed a variety of diagnoses,
                      including pineoblastomas (n = 27), high-grade gliomas
                      (n = 17), embryonal tumors (n = 7), atypical
                      teratoid/rhabdoid tumors (n = 3), and ependymomas
                      (n = 2). Thus, $39\%$ overall and $71\%$ of nonpineal
                      tumor diagnoses were discrepant with histopathology. Tumor
                      location, size, margins, and edema were predictors of
                      embryonal-versus-nonembryonal tumors. Larger size and
                      ill-defined margins correlated with poor event-free
                      survival, while metastatic disease by MR imaging did not.In
                      nonpineal locations, only a minority of histologically
                      diagnosed primitive neuroectodermal tumors are embryonal
                      tumors; therefore, high-grade glioma or ependymoma should be
                      high on the radiographic differential. An understanding of
                      molecularly defined tumor entities and their relative
                      frequencies and locations will help the radiologist make
                      more accurate predictions of the tumor types.},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31601576},
      doi          = {10.3174/ajnr.A6253},
      url          = {https://inrepo02.dkfz.de/record/147334},
}